Tocilizumab for severe chest crisis in sickle cell disease
Part of Blood & lymphatic, Genetic & congenital, Lungs & breathing clinical trials.
This trial tests if the drug tocilizumab can help treat acute chest syndrome, a serious lung complication of sickle cell disease. It is for people with sickle cell disease who are hospitalized and need oxygen or breathing support. The study compares tocilizumab to a placebo to see if it speeds up recovery.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have sickle cell disease of any type (like SS, SC, or S-beta thalassemia).
- You are at least 2 years old.
- You are in the hospital for acute chest syndrome (fever and/or breathing problems with a new finding on a chest X-ray or CT scan).
- You need extra oxygen (at least 2 liters per minute) or a breathing machine for less than 48 hours.
- If you are a woman who can become pregnant, you must have a negative pregnancy test and use effective birth control for 3 months after treatment.
- You must not have certain other serious infections or have taken certain other medicines recently.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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