Clinical trials
Depression, Unipolar clinical trials
Below are recruiting depression, unipolar clinical trials, each written for real people, not researchers. We’re tracking 22 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06860165Recruiting
Mood tracking app study for adults with depression
This study tests a smartphone app (EmoDTx) that monitors mood in people with unipolar depression. It aims to see if the app can provide helpful digital measurements of your mood.
Changé, FranceAges 18 years+ - NCT06092411Recruiting
CBT and light therapy for depressed youth who are night owls
This trial tests if combining cognitive behavioral therapy (CBT) with bright light therapy (BLT) helps Chinese teenagers and young adults who have depression and a natural tendency to stay up late. The goal is to improve mood and sleep patterns.
Hong KongAges 12–20 - NCT07266545RecruitingPhase 4
RNA markers for antidepressant response in depression
This study looks at how RNA might help predict which antidepressant works best for you. It tests two medications: vortioxetine and cariprazine, in people with major depressive disorder or bipolar depression.
Rochester, MinnesotaAges 18–65 - NCT06472492Recruiting
Yoga for thinking and memory after depression
This study tests whether yoga can help improve thinking and memory in people who have had depression but are now feeling better. You would participate in a yoga program and researchers will see if it helps your cognitive skills.
Bengaluru, KarnatakaAges 18–60 - NCT06462196Recruiting
Study of Depression, Bipolar Disorder & Suicide Risk
This study looks at how depression, bipolar disorder, and suicide risk naturally change over time. It aims to better understand these conditions so doctors can improve treatments.
Bethesda, MarylandAges 18–120 - NCT06534684Recruiting
Brain stimulation (iTBS) for depression and thinking changes
This study tests whether a type of brain stimulation called iTBS can improve depression and thinking skills. It uses a magnetic coil over the scalp and is done on multiple days.
TromsøAges 22–65 - NCT05958940Recruiting
Bright light therapy study for depression
This trial studies whether daily bright light therapy can reduce depressive symptoms. It’s for adults with depression (including some with bipolar depression), and you would fill out questionnaires and be screened for safety.
EindhovenAges 18–65 - NCT07684911Recruiting
Long-term effects of TMS for depression
This study looks at how well the benefits of transcranial magnetic stimulation (TMS) last over time for people with depression that didn't get better with other treatments. It also uses brain scans to find markers that might predict who will keep doing well.
RennesAges 18 years+ - NCT06363981Recruiting
Brain stimulation for depression, sleep and memory problems
This study tests a non-invasive brain stimulation treatment (called rTMS) to help with depression, sleep problems, and memory or concentration issues. It's designed for people with moderate to severe depression who also have trouble sleeping and thinking clearly.
KrakowAges 18–65 - NCT06371352Recruiting
Brain stimulation for sleep and fatigue in depression
This study tests a noninvasive brain stimulation treatment (theta burst stimulation) to see if it can improve sleep, reduce daytime sleepiness, and ease fatigue in people with depression.
WarsawAges 18–65 - NCT07042217Recruiting
Brain stimulation for depression
This trial tests if a gentle electrical current applied to the head can help people with major depression. It's for adults currently in a depressive episode who haven't found relief from at least two previous antidepressants.
Woodbridge, New JerseyAges 22 years+ - NCT05011864Recruiting
Tele-therapy for depression and fall risk in homebound seniors
This study tests a combined phone/online counseling program to help treat depression and reduce fall risk in homebound older adults. It may help you feel better emotionally and become safer at home.
Austin, TexasAges 50–100 - NCT05640089Recruiting
Brain training with fMRI feedback for depression
This trial tests whether using real-time brain scan feedback (fMRI neurofeedback) can help reduce depressive symptoms. You may be eligible if you have depression that is still active despite being on antidepressant medicine.
MaastrichtAges 18 years+ - NCT07007247Enrolling by invitation
Digital aftercare for teens with depression after hospital discharge
This pilot study tests a digital program to support adolescents aged 12–17 with depression after they leave the hospital. It aims to help prevent relapse and improve well-being using a smartphone, tablet, or computer.
HamburgAges 12–17 - NCT07002554Enrolling by invitationPhase 2
Bright light therapy for older adults with depression in the hospital
This study tests whether bright light therapy helps reduce depression in adults aged 60 and older who are hospitalized for depression. If you are currently staying on the Senior Care Unit at MUSC and have a depression diagnosis, this treatment might be an option for you.
Charleston, South CarolinaAges 60 years+ - NCT06973759Recruiting
Bright light therapy for teens with depression who are night owls
This study tests whether bright light therapy in the morning can help Chinese teenagers with depression who tend to stay up late and feel more energetic in the evening. It aims to see if adjusting your body clock with light can improve mood.
Hong Kong, Hong KongAges 12–19 - NCT05400382Recruiting
Mindfulness for depression and pain after cesarean delivery
This study tests whether a mindfulness program can help new mothers manage pain and depression after a planned cesarean delivery. You might be eligible if you are a woman of color or non-Hispanic White with a history of depression and are scheduled for a planned C-section.
Champaign, IllinoisAges 18–45 - NCT05570110RecruitingPhase 1/Phase 2
Enoxolone for depression, using body signals to track response
This study tests enoxolone, a medication related to licorice, in people with unipolar (non-bipolar) major depression. It also looks at your body “signals” (biomarkers) to see which ones match with whether treatment helps.
Marburg, HesseAges 18 years+ - NCT06392867Recruiting
Brain stimulation for stubborn depression: intensity study
This study tests a type of brain stimulation called TMS (transcranial magnetic stimulation) for people with depression that hasn't improved with at least two antidepressants. Researchers want to see if a faster version of TMS (theta-burst stimulation) helps reduce depression symptoms.
Hong KongAges 18–70 - NCT05017311RecruitingPhase 4
Testing a depression medication plan using symptom predictions
This Phase 4 study tests an “optimized” medication approach for adults with major depressive disorder (unipolar depression) based on how you respond over time. It may help your care team choose treatments more effectively and reduce trial-and-error.
Calgary, AlbertaAges 18–65 - NCT07216404RecruitingPhase 2
Psilocybin therapy for depression in lung cancer patients
This trial tests whether a psychedelic-assisted therapy can help treat major depression in people with non-small cell lung cancer. If you have moderate to severe depression and are receiving cancer treatment, you may be able to join.
Columbus, OhioAges 18 years+ - NCT07462637Recruiting
Light therapy for depression in unipolar and bipolar disorder
This study tests how well light therapy works for moderate to severe depression in people with or without bipolar disorder. It includes a possible MRI brain scan to understand how light affects the brain. You must not have certain eye conditions or high suicide risk.
ParisAges 18–65
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Common questions
- Are there clinical trials for depression, unipolar?
- Yes. Clin2 currently lists 22 recruiting depression, unipolar studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression, unipolar trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression, unipolar trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.