Combination diuretic therapy for heart failure fluid overload
Treatments studied
Part of Heart & circulation, Kidney & urinary clinical trials.
This trial tests a combination of water pills (diuretics) to help remove extra fluid in people hospitalized with acute decompensated heart failure (sudden worsening of heart failure). It aims to find a safe and effective way to reduce swelling and fluid buildup.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 64 years old.
- You are in the hospital for acute decompensated heart failure with signs of fluid overload (like leg swelling, fluid in the belly or lungs, or high pressure in neck veins).
- You do not have acute kidney injury at the time of admission.
- Your kidneys are working well enough (eGFR over 30 mL/min) and you are not on dialysis.
- You are not pregnant, breastfeeding, or using certain water pills like acetazolamide or metolazone in the last month.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if adding a diuretic (water pill) called acetazolamide to usual care can help you get rid of extra fluid faster while you are in the hospital for worsening heart failure.
This study compares two medicines—acetazolamide and dapagliflozin—to see which works better at removing extra fluid in people hospitalized for worsening heart failure. It may help decide the best treatment for fluid overload.
This study tests whether adding acetazolamide or metolazone to standard treatment helps remove extra fluid better in people hospitalized for heart failure. It aims to find a safer and more effective option for managing fluid overload.
This trial tests whether adding an oral water pill (acetazolamide) to standard IV furosemide helps people with acute heart failure who have fluid overload. It aims to see if the combination improves outcomes better than furosemide alone.
This trial tests a device to help the kidneys remove excess fluid in people hospitalized for worsening heart failure who are not responding well to standard diuretic (water pill) therapy. It aims to improve heart and kidney function.
This trial tests a device designed to safely remove extra fluid from patients hospitalized with worsening heart failure. It may help those who are not responding well to standard water pills (diuretics).
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