Comparing Two Water Pills for Worsening Heart Failure
Treatments studied
Part of Heart & circulation clinical trials.
This study compares two medicines—acetazolamide and dapagliflozin—to see which works better at removing extra fluid in people hospitalized for worsening heart failure. It may help decide the best treatment for fluid overload.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You are in the hospital for worsening heart failure with signs of too much fluid (like leg swelling, belly fluid, or fluid in the lungs).
- You have had a test of your heart's pumping strength (ejection fraction or LVEF) within the past year.
- You are not currently taking a medicine called acetazolamide (Diamox).
- You have not taken a medicine like dapagliflozin (Farxiga) or empagliflozin (Jardiance) in the last 2 days.
- Your kidney function is good enough (eGFR at least 20).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if adding a diuretic (water pill) called acetazolamide to usual care can help you get rid of extra fluid faster while you are in the hospital for worsening heart failure.
This trial tests a combination of water pills (diuretics) to help remove extra fluid in people hospitalized with acute decompensated heart failure (sudden worsening of heart failure). It aims to find a safe and effective way to reduce swelling and fluid buildup.
This study tests whether adding acetazolamide or metolazone to standard treatment helps remove extra fluid better in people hospitalized for heart failure. It aims to find a safer and more effective option for managing fluid overload.
This trial tests whether adding an oral water pill (acetazolamide) to standard IV furosemide helps people with acute heart failure who have fluid overload. It aims to see if the combination improves outcomes better than furosemide alone.
This trial tests a device designed to safely remove extra fluid from patients hospitalized with worsening heart failure. It may help those who are not responding well to standard water pills (diuretics).
This trial tests if dapagliflozin or acetazolamide works better for people hospitalized with heart failure who have extra fluid in their body (congestion). The study will compare how well each medication helps remove fluid when used with standard IV diuretics.
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