Blood-Guided Chemoradiation for HPV-Positive Throat Cancer
Treatments studied
Part of Cancer, Ear, nose & throat, Mouth & dental clinical trials.
This study tests whether a blood test that looks for circulating HPV DNA (ctDNA) can help doctors decide if you need chemotherapy after surgery for HPV-positive throat cancer. After you have surgery to remove the cancer, you receive radiation (possibly with chemotherapy) — the results of the blood test guide whether or not to add chemo.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have HPV-positive (p16-positive) oropharyngeal cancer that has spread to neck lymph nodes.
- You’ve had or will have complete surgical removal of the tumor (using robotic surgery) and a neck dissection.
- At least one high-risk feature after surgery (like larger tumor size, multiple positive nodes, or cancer in the surgical margins).
- A blood test (NavDx) must confirm you have detectable HPV DNA in your blood or tumor.
- You must be in good general health (ECOG 0-2) and have normal kidney, liver, and blood cell counts before starting chemoradiation.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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