Clin2
NCT06473116Possibly a fitNot yet recruiting

Epinephrine vs isoprenaline for cardiac arrest with no heartbeat

Out-Of-Hospital Cardiac Arrest

Part of Heart & circulation clinical trials.

This trial compares two medications, epinephrine and isoprenaline, given to people who have a cardiac arrest (heart stops beating) with a specific heart rhythm called asystole (flatline). The goal is to see which drug is better at restarting the heart and improving chances of survival.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 4
Enrollment
1,178 people
Ages
18 years to 85 years
Study type
Interventional

Who can take part

  • You must be 18 years or older.
  • Your cardiac arrest must have been witnessed (someone saw it happen).
  • The first heart rhythm recorded by emergency services must be asystole (flatline).
  • Emergency medical services must have started or continued advanced life support (like CPR and breathing support).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT05895838Recruiting· Phase 3
Trial for medicines after out-of-hospital cardiac arrest

This Phase 3 trial studies treatments given after a person survives an out-of-hospital cardiac arrest to improve recovery and survival. It is for patients who stay unconscious for a short time after circulation returns, and who meet safety conditions.

Copenhagen, Capital Region of Denmark
NCT06203847Recruiting
Prehospital drug combo for cardiac arrest

This trial tests whether a combination of three medications (epinephrine, vasopressin, and a steroid) given by paramedics before arriving at the hospital can improve survival for adults who have a cardiac arrest outside of a hospital. It is only for patients who are treated by specially trained paramedics and meet specific medical criteria.

Taipei
NCT06805344Not yet recruiting
Extracorporeal life support for cardiac arrest

This trial tests a treatment called ECPR, which uses a machine to pump blood and add oxygen after a cardiac arrest that doesn't respond to standard CPR and shocks. It aims to improve survival and recovery by quickly starting this support in the hospital.

NCT05969028Recruiting
Testing breathing and chest compression timing for out-of-hospital cardiac arrest

This trial studies the best timing for chest compressions and airway management for adults who have sudden cardiac arrest outside the hospital. It may help improve survival chances by guiding first EMS responders on how to act sooner and more consistently.

Seattle, Washington
NCT06744361Recruiting· Phase 2
Ketamine after cardiac arrest to protect the brain

This trial tests whether the sedative drug ketamine, given after a cardiac arrest, can help protect the brain. It's for people whose heart stopped outside the hospital due to a shockable rhythm and who needed a breathing tube placed by emergency responders.

Copenhagen
NCT03826524Recruiting· Phase 4
Comparing two doses of epinephrine for cardiac arrest

This study looks at whether a higher dose of epinephrine (a medicine that helps restart the heart) is better than the standard dose for people whose heart has stopped outside of a hospital. It aims to see if one dose leads to better survival and recovery.

Victoria, British Columbia

Hear when a new Out-Of-Hospital Cardiac Arrest trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.