Online therapy and IV ketamine for severe depression with suicide risk
Treatments studied
Part of Mental health clinical trials.
This study tests whether adding an online therapy (i-CBT) to intravenous (IV) ketamine is better than IV ketamine alone for people with treatment-resistant depression who are also thinking about suicide. You'll receive either ketamine or a comparison drug (midazolam), plus the online therapy, in a hospital setting.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 21 and 65 years old.
- You have a current major depressive episode (without psychosis) that has not responded to at least 2 different antidepressants.
- You have recent suicidal thoughts or behaviors.
- You have reliable internet access and a device (smartphone, computer, etc.).
- You can read and speak English well enough for online therapy.
- You are not pregnant, breastfeeding, or planning pregnancy, and you agree to use effective birth control if sexually active.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if adding virtual reality to ketamine treatments can help people with depression that hasn't improved with other treatments. You'll receive IV ketamine as prescribed by your doctor and also use a virtual reality headset during sessions.
This Phase 4 study tests whether ongoing treatment with ketamine or esketamine can reduce suicidal thoughts in people with major depression who are at high risk. Because the study focuses on long-term maintenance, you’d receive treatment over time while being closely monitored for safety and mental health changes.
This early-stage study tests ketamine and looks at what brain changes may explain why it helps people with major depression that hasn’t improved with usual treatments. You may be asked to stay in the hospital and complete detailed interviews, mood rating scales, and brain imaging.
This trial tests whether a combination of ketamine (given through an IV) and talk therapy can help people with depression that hasn't responded to other treatments. If you have tried multiple antidepressants and therapy without success, this study may offer a new option.
This study compares ketamine alone to ketamine combined with psychotherapy for treating depression. It may help if you have moderate to severe depression and want to see if adding talk therapy improves results.
This early-stage study tests how ketamine given once and then repeatedly may change brain signals and related biomarkers in people with major depression. If you’re eligible, the team will use brain imaging and assessments to see who responds and why.
Hear when a new Major Depressive Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.