Ranolazine for muscle cramps in ALS
Treatments studied
Part of Brain & nervous system, Hormones & metabolism clinical trials.
This trial tests if a heart medication called ranolazine can reduce painful muscle cramps in people with ALS. If you experience frequent cramps and meet the other criteria, this study may be an option for you.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years old or older.
- You have been diagnosed with ALS (definite, probable, or possible).
- Your breathing strength (FVC) is at least 50% of normal.
- You can swallow pills now and for the duration of the study.
- You have had 4 or more cramps per week during a 2-week screening period.
- You have had ALS for at least 5 years.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a supplement called acetyl-L-carnitine (ALCAR) to see if it can slow the progression of ALS. It is for people in the early stages of the disease who are already taking riluzole and have good lung and muscle function.
This trial tests a new drug called TP04HN106 for people with ALS. It aims to see if it is safe and if it might slow down the disease. You may qualify if your breathing is still fairly good and you have been on a stable dose of riluzole.
This trial tests an experimental drug called MRG-001 for people with amyotrophic lateral sclerosis (ALS). It aims to see if the drug can help slow the progression of the disease.
This trial tests whether repetitive TMS (transcranial magnetic stimulation) can help people with ALS. It uses a special type of TMS that is repeated and measured. You would lie comfortably for about an hour while receiving the treatment.
This trial studies an experimental drug called LTX-002 for people with ALS. It aims to see if the drug is safe and can slow down the disease.
This trial tests whether adding two supplements (EH-301 and N-acetylcysteine) to the standard ALS medicine Riluzole can help slow the disease. It is for people diagnosed with ALS within the last 18 months who still have good breathing and daily function.
Hear when a new Amyotrophic Lateral Sclerosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.