Medications to protect thinking after brain radiation
Treatments studied
Part of Genetic & congenital, Injuries & trauma, Mental health clinical trials.
This trial tests whether starting two medicines early can help protect your memory and thinking abilities after whole-brain radiation for cancer that has spread to the brain. You would take memantine and pioglitazone while undergoing standard radiation treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have brain metastases (cancer that spread to the brain) that are newly diagnosed, but not too close to the memory center.
- Your overall health is fairly good (able to care for yourself, out of bed more than half the day).
- You have not had whole-brain radiation before.
- Your blood counts and liver/kidney function are within acceptable ranges.
- You are not pregnant, not breastfeeding, and willing to use birth control if needed.
- You have no severe heart problems, trouble swallowing, or history of allergic reaction to memantine or pioglitazone.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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