Sildenafil for newborn brain injury after birth asphyxia
Treatments studied
Part of Brain & nervous system, Genetic & congenital, Heart & circulation clinical trials.
This trial tests whether a liquid form of the medicine sildenafil can help repair brain damage in newborns who had a difficult birth and were treated with cooling. If your baby meets the cooling criteria and has brain injury on an MRI, this study may offer an additional treatment option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your baby was born at 36 weeks or later and weighed at least 1800 grams (about 4 pounds).
- There were signs of distress during birth, like a low cord blood pH or low Apgar score.
- Your baby had moderate to severe brain injury and received whole-body cooling within 6 hours of birth.
- A brain MRI on day 2 showed brain injury, but no major bleeding or other brain problems.
- Your baby does not have a complex heart defect, genetic syndrome, or a brain malformation.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 3 study tests whether cooling a newborn’s body can help babies with mild brain injury after a difficult birth. It aims to see if cooling improves brain-related outcomes compared with standard care.
This Phase 2 study tests whether sovateltide can improve safety and outcomes for babies whose brains may have been injured by low oxygen around birth. It focuses on babies who show signs of moderate to severe injury soon after delivery, and who receive standard supportive care.
This study looks at how children who received cooling treatment for brain injury at birth are doing in the long run. It aims to understand the lasting effects of this treatment, which might help doctors improve care for future babies.
This study tests two different pain medicines (dexmedetomidine and morphine) given to newborns during cooling therapy, which is a treatment to help reduce brain injury. The goal is to see which medicine works better for comfort and safety.
This study tests a special, non-invasive sensor (near-infrared light) to help doctors choose the best cooling treatment for some newborns after brain injury. It may improve how well cooling works and how safely it’s managed in the first week of life.
This study tests whether adding a medication called sildenafil (commonly used for blood pressure) to standard cooling treatment can improve brain recovery in newborn babies with brain injury from lack of oxygen. It aims to see if the combination is safe and effective in helping these babies develop better.
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