Sildenafil for newborn brain injury after birth asphyxia
Treatments studied
Part of Brain & nervous system, Genetic & congenital, Heart & circulation clinical trials.
This trial tests whether a liquid form of the medicine sildenafil can help repair brain damage in newborns who had a difficult birth and were treated with cooling. If your baby meets the cooling criteria and has brain injury on an MRI, this study may offer an additional treatment option.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your baby was born at 36 weeks or later and weighed at least 1800 grams (about 4 pounds).
- There were signs of distress during birth, like a low cord blood pH or low Apgar score.
- Your baby had moderate to severe brain injury and received whole-body cooling within 6 hours of birth.
- A brain MRI on day 2 showed brain injury, but no major bleeding or other brain problems.
- Your baby does not have a complex heart defect, genetic syndrome, or a brain malformation.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at the long-term health and development of babies who had a specific brain injury at birth and were treated with whole-body cooling. It may help doctors understand what outcomes to expect years later and how to best support families.
This Phase 3 study tests whether cooling a newborn’s body can help babies with mild brain injury after a difficult birth. It aims to see if cooling improves brain-related outcomes compared with standard care.
This Phase 2 study tests whether sovateltide can improve safety and outcomes for babies whose brains may have been injured by low oxygen around birth. It focuses on babies who show signs of moderate to severe injury soon after delivery, and who receive standard supportive care.
This study tests a special, non-invasive sensor (near-infrared light) to help doctors choose the best cooling treatment for some newborns after brain injury. It may improve how well cooling works and how safely it’s managed in the first week of life.
This trial tests whether adding sildenafil to standard cooling treatment helps newborns who had a lack of oxygen to the brain. It aims to see if this combination can reduce brain damage and improve outcomes.
This early study tests whether giving melatonin to newborns with hypoxic-ischemic encephalopathy (brain injury from not enough oxygen around birth) can help protect the brain while they are cooled (therapeutic hypothermia). It may be most relevant if your baby shows early brain-injury signs and meets specific blood test and birth-history timing criteria.
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