Mapping carotid plaque inflammation with a new MRI contrast agent
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests a new contrast agent called ABL-101 that helps MRI scans show inflammation in the fatty buildup (plaque) in the carotid artery. The goal is to better identify dangerous plaque before surgery to remove it, which may help prevent strokes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a blocked carotid artery (at least 50% narrowing if you've had symptoms like a mini-stroke, or at least 60% narrowing if you haven't) confirmed by two imaging tests (like ultrasound or CT scan).
- You are scheduled to have surgery (carotid endarterectomy) to remove the blockage, but not earlier than 2 days from now.
- You are not pregnant or breastfeeding.
- You do not have bleeding disorders, a weakened immune system, or severe other illnesses (like kidney or heart failure).
- You are able to have an MRI (no incompatible metal implants, no claustrophobia).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study uses special ultrasound and MRI scans to look closely at plaque buildup in the neck arteries. The goal is to better understand the plaque, which may help doctors plan safer treatments for people with narrowed arteries.
This study tests whether a special type of PET/MRI scan can help doctors see inflammation in the carotid artery after a stroke or mini-stroke. By using a radioactive tracer, the scan may identify which patients have dangerous plaque buildup that could lead to another stroke.
This study tests a special dye that makes inflamed areas in artery plaques glow during surgery. It may help doctors see which plaques are dangerous and guide treatment.
This Phase 1 study tests whether a special PET scan can detect a specific inflammation signal (CCR2) in atherosclerosis—fatty plaque buildup in blood vessels. It may help future doctors better see which plaques are more inflamed and potentially more dangerous.
This trial tests a special balloon (IVL) to treat hardened plaque in the neck arteries that supply blood to the brain. It is for people who need a stent but whose previous balloon treatment did not work well.
This study investigates the build-up of fatty deposits called plaques in arteries of the brain and neck using two different strengths of MRI scanners. It aims to understand how well these MRI techniques can image the plaques, which could help doctors better diagnose and manage stroke risk.
Hear when a new Carotid Endarterectomy trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.