Clin2
NCT06866600Worth exploringNot yet recruiting

Stem cell heart injections for severe heart failure

Heart FailureHeart Failure At NYHA Stage III or IV

Part of Heart & circulation clinical trials.

This trial tests whether injecting special heart muscle cells (made from stem cells) during a heart bypass or a heart pump surgery can help improve your heart's function. It is for people with severe heart failure who are already planning one of these surgeries.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1/Phase 2
Enrollment
40 people
Ages
35 years to 75 years
Study type
Interventional

Who can take part

  • You are between 35 and 75 years old.
  • You have been diagnosed with end-stage heart failure and still have significant symptoms (NYHA class III or IV) despite taking heart medicines.
  • Your heart's pumping function is severely reduced (LVEF 35% or less) as seen on an MRI.
  • You are already scheduled for either a heart bypass surgery (CABG) or a left ventricular assist device (LVAD) implantation.
  • You have not had a pacemaker, defibrillator (ICD), or CRT device implanted.
  • You have not had a heart attack, heart procedure (like stents), or stroke in the last month, and you do not have other major health conditions like cancer or immune diseases.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07496372Recruiting· Phase 3
Stem cell injection for advanced heart failure

This trial tests a treatment made from stem cells that are turned into heart muscle cells and injected directly into the heart. It is for people with advanced heart failure who are already on the best available medicines and who are scheduled to have bypass surgery.

Tianjin, Tianjin Municipality
NCT07347197Not yet recruiting· Phase 1/Phase 2
Heart cell injection for heart failure with reduced pumping function

This trial tests whether injecting lab-grown heart cells into the heart can help people with heart failure whose heart pumps less than 40% of normal. It may help improve heart function and reduce symptoms.

NCT06154044Recruiting· Phase 2
Cell therapy for heart recovery with LVAD support

This trial tests whether injecting special cells (cell therapy) can help the heart recover in people with advanced heart failure who are getting a mechanical heart pump (LVAD). It may offer a new way to improve heart function and quality of life.

Ljubljana
NCT04396899Recruiting· Phase 1/Phase 2
Stem cell heart patch for advanced heart failure

This early-phase study tests a lab-made heart tissue (“engineered myocardium”) placed surgically to help the heart work better in people with advanced heart failure. It mainly checks safety first, and also looks for signs the patch can improve heart function in selected patients.

Göttingen, Lower Saxony
NCT06956807Not yet recruiting· Phase 1
Heart patch with stem cells for damaged heart muscle

This trial tests whether placing a special membrane with stem cells on the heart during bypass surgery can help improve heart function in people with a weak heart after a previous heart attack.

Katowice - Ochojec
NCT06705023Recruiting· Phase 2
Fat-derived cell therapy for heart failure

This study tests whether taking a small amount of your own belly fat (through liposuction), processing it, and injecting the cells back into your heart can improve heart function in people with chronic heart failure due to blocked arteries. The trial is for patients whose heart pumps weakly (ejection fraction of 40% or less) and who are already on standard medications.

Astana

Hear when a new Heart failure trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.