Anti-CD25 antibody to prevent graft-versus-host disease in high-risk adults
Treatments studied
Part of Immune system & allergy clinical trials.
This trial tests whether an antibody called anti-CD25 can help prevent a serious side effect (graft-versus-host disease) in adults getting a stem cell transplant for blood disorders. It is for people considered high-risk based on a special scoring model.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 16 years or older.
- You have a blood disorder and are scheduled to receive a stem cell transplant from a donor (allogeneic HSCT).
- You have not had a previous stem cell transplant (this is your first).
- You are not allergic to the study drug (a recombinant humanized anti-CD25 antibody).
- If you are able to become pregnant, you agree to use effective birth control during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests a combination of a steroid and a humanized antibody (called CD25 monoclonal antibody) as the first treatment for moderate to severe acute graft-versus-host disease (aGVHD) after a stem cell transplant. The goal is to see if this combination is safer and more effective than steroids alone.
This trial tests whether giving a special type of immune-regulating cells (iMSCs) can help prevent a serious complication called graft-versus-host disease (GvHD) after a stem cell transplant. It’s for people who are at higher risk of developing GvHD based on a blood test taken a week or two after their transplant.
This trial tests whether adding a monoclonal antibody (CD25) to standard therapy can reduce severe acute GVHD (a serious immune reaction) after umbilical cord blood transplant for blood cancers. It aims to improve outcomes for patients with malignant hematologic diseases.
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This study is testing whether giving a special antibody (anti-CD25) before a half-matched stem cell transplant can prevent a common side effect called graft-versus-host disease (GVHD), where donor cells attack your body. It is for people with blood cancers who are getting this type of transplant.
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