Study of tenecteplase into the artery after clot removal for stroke
Part of Brain & nervous system, Heart & circulation clinical trials.
This study tests a clot-dissolving drug called tenecteplase given directly into the artery after a mechanical thrombectomy (clot removal). The goal is to see if it helps improve blood flow to the small vessels in the brain after the main clot is removed.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You are having a stroke caused by a blockage in a large artery in the front of the brain (confirmed by imaging).
- You are scheduled to have a procedure to remove the clot (mechanical thrombectomy).
- It has been less than 24 hours since your stroke began.
- You do not have a bleeding disorder, active internal bleeding, or recent use of blood thinners that would increase bleeding risk.
- You have not had a stroke or received a clot-busting drug in the last 3 months.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial tests whether a clot-busting drug called tenecteplase works safely in people having a stroke who are already taking certain blood-thinning medications (like apixaban or rivaroxaban). The goal is to see if it can restore blood flow to the brain better than current treatments.
This trial tests whether giving a clot-busting drug called tenecteplase directly into the brain artery after a successful mechanical clot removal can improve recovery for people with a certain type of stroke. The goal is to see if it safely helps clear any remaining tiny clots and reduces disability.
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This trial tests a clot-busting drug called tenecteplase given directly into the brain artery for people having a moderate stroke caused by a blockage in a medium-sized blood vessel. The goal is to see if it helps improve recovery when given within 24 hours of stroke symptoms starting.
This trial tests a clot-busting drug called tenecteplase, given directly into the blocked artery, for people who have had a stroke caused by a medium-sized brain vessel blockage within the last 24 hours. It aims to see if this treatment is safe and effective in improving recovery.
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