Preventing confusion after hip or knee replacement surgery
Treatments studied
Part of Brain & nervous system, Mental health clinical trials.
This study tests two medicines (ketamine and dexmedetomidine) used during joint replacement surgery to see if they can prevent confusion (called delirium) that sometimes happens after surgery. Both medicines are commonly used in anesthesia, and the goal is to keep you mentally clear as you recover.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are scheduled for a hip or knee replacement surgery
- You are between 18 and 100 years old
- You are in good health overall (no severe heart, kidney, or liver conditions)
- You do not have a pre-existing memory problem or dementia
- You can hear and speak well enough to answer questions and do memory tests
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests whether adding a medicine called dexmedetomidine to the spinal anesthesia can help prevent confusion (called delirium) after hip fracture surgery in older adults. It might help you recover more clearly and avoid post-surgery confusion.
This study looks at whether a medicine that reverses sedation can help your thinking and memory recover faster after hip replacement surgery. You'll receive spinal anesthesia, and you'll get either the study drug or a placebo to see how it affects your brain function after the operation.
This study tests whether a medicine called esketamine, given during and after surgery, can lower the chance of confusion or memory problems in older adults. It is for people aged 65 to 90 having non-cardiac surgery that lasts at least 2 hours.
This study looks at how different pain management methods after knee replacement surgery affect the risk of confusion (delirium) in older patients. It aims to find safer ways to manage pain and reduce confusion after surgery.
This trial tests if giving either oral melatonin or lidocaine during surgery can reduce the chance of confusion (delirium) in older adults after total hip replacement. It compares these two approaches to standard care.
This trial tests giving either lidocaine or dexmedetomidine during abdominal surgery to see if it helps keep the brain healthy and lowers the chance of waking up confused or agitated. It is for older adults having planned abdominal surgery who are otherwise in fairly good health.
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