Fenofibrate to prevent nerve damage from multiple myeloma treatment
Treatments studied
Part of Blood & lymphatic, Brain & nervous system, Cancer, Heart & circulation, Immune system & allergy clinical trials.
This trial tests if adding fenofibrate to standard treatment (VRd) can prevent nerve damage (peripheral neuropathy) caused by bortezomib in patients with newly diagnosed multiple myeloma. If you are starting VRd therapy, this study may help reduce pain or numbness from the chemotherapy.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have been newly diagnosed with multiple myeloma and are about to start treatment with VRd (bortezomib, lenalidomide, dexamethasone)
- You are in generally good physical condition (ECOG score less than 2, meaning you can do most daily activities)
- Your blood counts (neutrophils, platelets, hemoglobin) and liver/kidney function are within normal limits
- You have not used certain other nerve-toxic drugs or supplements (like high-dose vitamins A, C, E) recently, and you do not have pre-existing nerve damage from diabetes or other causes
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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