Melatonin for sleep and brain health in cirrhosis
Treatments studied
Part of Brain & nervous system, Digestive system, Hormones & metabolism, Mental health clinical trials.
This study tests whether melatonin (a natural sleep hormone) can improve sleep and thinking abilities in people with cirrhosis and liver-related brain fog. It aims to see if better sleep leads to clearer thinking.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have cirrhosis (scarring of the liver) with signs of high pressure in the liver veins or a history of liver-related complications
- You have been diagnosed with hepatic encephalopathy (confusion or brain fog from liver disease) or have trouble with thinking and memory
- You have trouble sleeping most nights (score of 5 or more on a standard sleep questionnaire)
- You own a smartphone (iPhone with iOS 14+ or Android 8.0+) that can download the Oura app
- You are not currently taking melatonin 3 or more times a week, or you can stop taking it for the study
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies rhythmic light therapy to help people with early Alzheimer’s or mild memory problems, especially when sleep is getting worse. If you fit the sleep and vision/medical safety requirements, the study may see whether the therapy improves sleep and thinking-related symptoms.
This study tests whether taking 5 mg of melatonin can improve thinking and brain health over time in older adults with early, mild symptoms. You may help researchers learn which brain changes and measures improve with melatonin.
This study tests whether taking melatonin for 3 months can improve brain structure and blood markers in people with memory problems or early Alzheimer's. It involves brain scans and simple tests of thinking and physical function.
This study tests whether adding a melatonin supplement to a type of talk therapy for insomnia (called CBT-I) helps older adults sleep better. It aims to improve sleep quality and reduce insomnia symptoms.
This Phase 2 study tests whether melatonin can improve sleep and possibly outcomes related to diabetic retinopathy (damage to the retina from diabetes). It also checks whether it affects related symptoms while keeping people safe.
This study tests whether melatonin (a natural sleep hormone) can improve sleep quality in people with inflammatory bowel disease (IBD) whose disease is quiet (in remission). If you have IBD and trouble sleeping, you may be able to join.
Hear when a new Hepatic Encephalopathy trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.