New pacemaker vs standard cardiac therapy for heart failure
Part of Heart & circulation clinical trials.
This study tests a newer type of pacemaker that paces the heart's left bundle branch area, compared to the usual cardiac resynchronization therapy. It is for people with heart failure who need a combined pacemaker-defibrillator (CRT-D) and have a specific heart rhythm pattern (left bundle branch block) with reduced pumping strength.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and need a new CRT-D device (a special pacemaker with a defibrillator) for the first time.
- Your heart's pumping ability (LVEF) is 35% or less, measured in the last 6 months after at least 3 months of recommended heart failure medications.
- You have symptoms of heart failure (NYHA class II to IV) despite taking optimal heart failure drugs (such as ACE inhibitors/ARBs/ARNIs, beta blockers, mineralocorticoid receptor antagonists, and SGLT2 inhibitors) for at least 3 months.
- You have a specific electrical heart pattern called left bundle branch block (LBBB) with a wide QRS (>=130 ms in women or >=140 ms in men).
- You agree to use a remote monitoring system (LATITUDE NXT) and can attend follow-up visits at the study site.
- You are not currently in permanent or persistent atrial fibrillation and do not have other conditions requiring a high amount of heart pacing.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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