Clin2
NCT07132398Possibly a fitNot yet recruiting

Slow vs. rapid steroid taper with inebilizumab for NMOSD

Neuromyelitis Optica (NMO)Neuromyelitis Optica Spectrum Disorders (NMOSD)

Part of Brain & nervous system, Eyes & vision, Immune system & allergy clinical trials.

This trial is for people with NMOSD who have recently had an attack. It compares two ways of slowly reducing steroid treatment while also receiving an experimental drug called inebilizumab, to see which approach helps prevent future attacks better.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
170 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must be at least 18 years old.
  • You must have a confirmed diagnosis of NMOSD.
  • You must test positive for AQP4 antibodies in your blood.
  • You must have had an attack within the last month, and be currently on a daily steroid dose of 60 mg prednisone (or equivalent).
  • You cannot be pregnant, breastfeeding, or planning pregnancy during the study.
  • You cannot have serious active infections like tuberculosis, hepatitis B or C, or HIV, or other conditions like severe liver or kidney problems.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07420296Recruiting· Phase 3
Modified zipper therapy for AQP4-positive neuromyelitis optica

This trial tests a new treatment called modified zipper therapy for people with neuromyelitis optica spectrum disorder (NMOSD) who have a specific antibody (AQP4-IgG) in their blood. It aims to stop a recent attack and improve recovery.

Tianjin
NCT07762872Recruiting
Satralizumab during early NMOSD attacks

This study looks at how well the medication satralizumab works when started early during an NMOSD attack, along with standard treatments. The aim is to see if adding this drug can help reduce the impact of the attack and improve outcomes.

Beijing, Beijing Municipality
NCT07159893Not yet recruiting
Inectolizumab with steroids for first attack of NMOSD

This trial tests a new drug called inectolizumab combined with steroids for people having their first attack of NMOSD, a rare autoimmune disease that can cause vision loss and paralysis. The goal is to see if this combination is safe and helps reduce symptoms.

NCT05549258Recruiting· Phase 2
Inebilizumab for children with NMOSD who had recent relapses

This trial studies whether inebilizumab can reduce illness activity in children with neuromyelitis optica spectrum disorder (NMOSD), a condition that can cause attacks affecting the eyes and spinal cord. It focuses on kids who have had recent relapses, meaning symptoms came back or worsened.

La Jolla, California
NCT07182409Not yet recruiting
Monoclonal antibody for acute neuromyelitis optica attacks

This trial tests a new antibody-based medicine to help people recover from an acute attack of neuromyelitis optica spectrum disorder (NMOSD), a condition that causes inflammation in the eyes and spinal cord. If you are having a recent flare-up and are already getting or planning to get steroid treatment, this study might offer an additional option to reduce damage and speed recovery.

NCT07010302Recruiting· Phase 4
Comparing medications for NMOSD

This trial compares several medications to see which works best for NMOSD, an autoimmune disease that can cause vision loss and paralysis. You must have a specific antibody (AQP4-IgG) to join.

Boston, Massachusetts

Hear when a new Neuromyelitis Optica Spectrum Disorders (NMOSD) trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.