Clin2
NCT07166393Possibly a fitNot yet recruiting

Valproic acid for traumatic brain injury

Moderate Traumatic Brain Injury (TBI)Severe Traumatic Brain Injury

Treatments studied

Part of Brain & nervous system, Injuries & trauma clinical trials.

This trial tests whether giving an FDA-approved seizure medication (valproic acid) soon after a moderate to severe brain injury can help reduce damage and improve recovery. If you arrive at the emergency room quickly after your head injury, you might be able to join.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2/Phase 3
Enrollment
432 people
Ages
18 years to 65 years
Study type
Interventional

Who can take part

  • You must be between 18 and 65 years old.
  • Your body mass index (BMI) must be between 18 and 35.
  • You have a moderate to severe brain injury (GCS score between 3 and 12).
  • Your head CT scan shows bleeding or other signs of injury (BIG 3 category).
  • You do not have serious liver, pancreas, or kidney problems, or low platelet counts.
  • Treatment must start within 2 hours of your injury.

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07072624Recruiting· Phase 4
Preventing seizures after severe head injury

This trial tests whether giving medication right after a serious head injury can prevent early seizures. It may help people with certain types of brain injuries seen on CT scans.

Chandigarh, Punjab
NCT06866691Recruiting· Phase 4
Seizure prevention after traumatic brain injury

This trial tests two medicines, levetiracetam and lacosamide, to see which works better at preventing seizures in people who have had a traumatic brain injury. The goal is to find the safest and most effective way to protect your brain after injury.

Winston-Salem, North Carolina
NCT04573803Not yet recruiting· Phase 3
Comparing two medicines to prevent or treat seizures after head injury

This study looks at two medicines (phenytoin and levetiracetam) to see which works better for treating or preventing seizures that can happen after a traumatic brain injury. It aims to find the safest and most effective option for patients.

NCT07535736Not yet recruiting
Seizure prevention after traumatic brain injury

This study tests whether giving an anti-seizure medicine soon after a traumatic brain injury can prevent seizures. It may help people who arrive at the hospital within 24 hours of their injury.

NCT04945213Recruiting· Phase 3
Biperiden to prevent seizures after traumatic brain injury

This trial tests whether biperiden can lower the chance of developing epilepsy after an acute traumatic brain injury (with bleeding or bruising seen on CT). If you qualify, you would get the medicine or a placebo soon after the injury, and researchers will compare outcomes.

Fortaleza, Ceará
NCT03559114Recruiting· Phase 3
Preventing blood clots after severe brain injury

This trial tests whether taking an anti–blood clot medicine (dalteparin) and using leg compression can reduce dangerous blood clots after a severe traumatic brain injury. It may help lower the chance of clots forming when people are immobile and at higher risk.

Calgary, Alberta

Hear when a new Severe Traumatic Brain Injury trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.