Valproic acid for traumatic brain injury
Treatments studied
Part of Brain & nervous system, Injuries & trauma clinical trials.
This trial tests whether giving a medicine called valproic acid shortly after a moderate to severe traumatic brain injury can help recovery. It aims to see if the drug can reduce damage and improve outcomes for people who arrive at the hospital quickly after their injury.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be between 18 and 65 years old
- Have a body mass index (BMI) between 18 and 35
- Have a moderate to severe traumatic brain injury, with a Glasgow Coma Scale score between 3 and 12
- Have a brain CT scan showing findings that match the injury criteria for this study
- Be able to receive the study drug within 120 minutes (about 2 hours) of the injury and arrive at the hospital within 90 minutes
- Not be pregnant, breastfeeding, or have a history of liver disease, low platelets, or allergy to this medication
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if adding memantine (a medication that protects brain cells) to standard care helps people recover from a mild or moderate traumatic brain injury within 24 hours of the accident.
This trial tests whether giving medication right after a serious head injury can prevent early seizures. It may help people with certain types of brain injuries seen on CT scans.
This trial tests whether taking an anti–blood clot medicine (dalteparin) and using leg compression can reduce dangerous blood clots after a severe traumatic brain injury. It may help lower the chance of clots forming when people are immobile and at higher risk.
This trial tests two medicines, levetiracetam and lacosamide, to see which works better at preventing seizures in people who have had a traumatic brain injury. The goal is to find the safest and most effective way to protect your brain after injury.
This Phase 3 study tests whether tranexamic acid can improve outcomes after traumatic brain injury. It may help by reducing bleeding and related damage soon after the injury in adults with mild to moderate cases.
This study tests an investigational treatment to improve outcomes after a recent non-penetrating traumatic brain injury (like a fall or car crash). It uses early CT/MRI imaging and a blood test soon after injury to see who benefits and how well the treatment works.
Hear when a new Severe Traumatic Brain Injury trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.