Clinical trials
Severe Traumatic Brain Injury clinical trials
Below are recruiting severe traumatic brain injury clinical trials, each written for real people, not researchers. We’re tracking 235 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07038889Recruiting
Virtual reality walking rehab for brain injury
This study tests whether using virtual reality during walking exercises can help people with traumatic brain injury improve their walking. It may be a more engaging way to do physical therapy.
Indianapolis, IndianaAges 18 years+ - NCT04499755RecruitingPhase 3
Nucleo CMP Forte for moderate to severe brain injury in children
This trial studies whether a supplement called Nucleo CMP Forte can improve outcomes after a moderate or severe traumatic brain injury in children. It may help families see if adding this treatment makes recovery better and safer.
TantaAges Up to 18 years - NCT02426255Recruiting
Study of serious injuries and complications after trauma
This study follows people with severe injuries (including head injuries and bleeding) to better understand serious complications that can happen after trauma. Your experience may help doctors predict and prevent these complications in the future.
AngersAges 15 years+ - NCT06163833RecruitingPhase 2
Stem cell treatment for severe traumatic brain injury
This study tests whether a treatment made from donor stem cells (called mesenchymal stromal cells) can help people recover from a severe traumatic brain injury. The cells are given through a vein within 48 hours of the injury.
Monza, MBAges 18–70 - NCT06177509Recruiting
Exercise therapy for mild traumatic brain injury
This trial tests if graded aerobic exercise can help people who have ongoing symptoms after a mild traumatic brain injury (concussion). It aims to see if carefully increasing exercise intensity improves tolerance to physical activity.
NesoddtangenAges 18–60 - NCT03655782Recruiting
Retraining brain pathways to improve memory after mild brain injury
This study tests a computer-based brain training program that may help improve memory and thinking skills in people who have had a mild traumatic brain injury or concussion. The training involves watching moving stripes on a screen and using arrow keys to respond, which is designed to retrain brain pathways.
San Diego, CaliforniaAges 18–60 - NCT04945213RecruitingPhase 3
Biperiden to prevent seizures after traumatic brain injury
This trial tests whether biperiden can lower the chance of developing epilepsy after an acute traumatic brain injury (with bleeding or bruising seen on CT). If you qualify, you would get the medicine or a placebo soon after the injury, and researchers will compare outcomes.
Fortaleza, CearáAges 18–75 - NCT07852728RecruitingPhase 2
Oxygen therapy for first responders after head injuries
This trial tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve thinking, mood, and overall well-being in first responders who have had a traumatic brain injury and still have symptoms. If you are a first responder dealing with ongoing brain injury symptoms, this study could help you find new ways to feel better.
Boise, IdahoAges 18–75 - NCT07852936Recruiting
Group therapy for emotional recovery after brain injury
This study tests a group-based talk therapy program designed to help people with acquired brain injury express and process emotions, aiming to improve mental health and coping after injury.
UppsalaAges 18 years+ - NCT07834476Enrolling by invitation
Setting treatment targets for severe head injury in children
This study looks at information from children who had a serious head injury. It uses data from special brain monitors to help doctors decide how to best manage these injuries.
Cambridge, CambridgeshireAges 1 month–18 years - NCT05095857RecruitingPhase 4
Ketamine to improve care in severe acute brain injury
This Phase 4 trial tests whether giving ketamine during anesthesia is safe and helpful for adults with severe sudden brain injuries after surgery. It may improve how patients are sedated and cared for while they are on a breathing machine.
CopenhagenAges 18 years+ - NCT07783828Recruiting
Chatbot-guided exercise for brain injury recovery
This trial tests whether a smartphone chatbot can help people recovering from a mild brain injury stick to a personalized, guided exercise program. It aims to improve their physical and mental well-being during recovery.
TaipeiAges 18 years+ - NCT07782216Recruiting
Studying brain proteins after acute brain injury
This study looks at how certain brain proteins (called biomarkers) behave in the blood after an acute brain injury. The goal is to see if these proteins can help doctors quickly assess the severity of the injury. Participation involves giving blood samples at specific times after your injury.
Pécs, BranyaAges 18 years+ - NCT03559114RecruitingPhase 3
Preventing blood clots after severe brain injury
This trial tests whether taking an anti–blood clot medicine (dalteparin) and using leg compression can reduce dangerous blood clots after a severe traumatic brain injury. It may help lower the chance of clots forming when people are immobile and at higher risk.
Calgary, AlbertaAges 18 years+ - NCT07749625Recruiting
Robotic arm training for recovery after stroke or injury
This study tests whether a robotic arm trainer can help improve arm movement and function in people with conditions like stroke, spinal cord injury, or brain injury. It may help you regain strength and control in your arm.
DhakaAges 18–60 - NCT07749612Recruiting
Robotic arm trainer for stroke and brain injury recovery
This trial tests a robotic device that helps people move their arms and hands during rehabilitation after a stroke, brain injury, or spinal cord injury. The goal is to improve arm function and make daily tasks easier.
DhakaAges 18–60 - NCT07739264Recruiting
Robotic hand training for arm weakness
This study tests a robotic hand training system called ZEPU-SG1PLUS to help improve arm and hand function in people with various conditions like stroke or injury. It aims to see if this device can help you move better and do daily activities more easily.
DhakaAges 18–60 - NCT07719595Recruiting
Vagus nerve stimulation for coma after brain injury
This trial tests if a gentle electrical stimulation of the vagus nerve (a nerve in the neck) can help people regain consciousness after a severe traumatic brain injury. It is for patients who are in a coma or minimally conscious state, and the treatment is given along with standard ICU care.
Stony Brook, New YorkAges 18 years+ - NCT07718321Recruiting
StimolIrpinia for brain injury rehab: a feasibility trial
This trial tests a new cognitive rehab tool called StimolIrpinia for people recovering from a serious brain injury. It aims to see if the tool is acceptable and helpful for improving thinking and memory.
Sant'Angelo dei Lombardi, AVAges 18–75 - NCT06146062RecruitingPhase 2
Stem cell therapy for severe traumatic brain injury
This trial tests whether a single infusion of stem cells from donated umbilical cord tissue can help calm inflammation in the brain after severe traumatic brain injury. It is for patients aged 18–50 who need brain pressure monitoring and are not responding to verbal commands 5 days after sedation is stopped.
ClamartAges 18–50 - NCT07664358Recruiting
Predicting lung injury after traumatic brain injury
This study looks at whether a simple blood test measuring fibrinogen and albumin levels can help predict if someone with a traumatic brain injury will develop a serious lung condition called acute respiratory distress syndrome (ARDS). It may help doctors identify patients who need extra monitoring and care.
Tanta, Gharbia GovernorateAges 18 years+ - NCT07670195RecruitingPhase 2
BCAAs for concussion recovery in young people
This study tests if a supplement called BCAAs (branched-chain amino acids) can help young people recover from a concussion. It aims to see if BCAAs improve symptoms compared to a placebo.
Havertown, PennsylvaniaAges 11–23 - NCT07655310Recruiting
Parent factors and CT use in kids with minor head injury
This study looks at how a parent's background and understanding of health information might affect whether a child with a minor head injury gets a CT scan. It aims to better understand these factors to improve care.
BursaAges Up to 17 years - NCT06571032Recruiting
EEG guidance for brain stimulation after severe injury
This study tests whether using brain wave monitoring (EEG) can help guide electrical stimulation treatment for people with severe traumatic brain injury. It aims to see if this approach can improve recovery.
Shanghai, Shanghai MunicipalityAges 18 years+
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Severe Traumatic Brain Injury trials by city
Studies with a site in or near these metro areas.
Severe Traumatic Brain Injury trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for severe traumatic brain injury?
- Yes. Clin2 currently lists 235 recruiting severe traumatic brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe traumatic brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe traumatic brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.