Morphine clearance study for sickle cell crisis in ICU
Part of Blood & lymphatic, Genetic & congenital, Lungs & breathing clinical trials.
This study looks at how the body clears morphine in adults with sickle cell disease who are in the intensive care unit (ICU) for a pain crisis or acute chest syndrome and are receiving morphine through a patient-controlled analgesia (PCA) pump. The goal is to understand how kidney function affects morphine breakdown.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have sickle cell disease (types SS, SC, S-beta+, or S-beta0)
- You are currently in an intensive care unit
- You are having a painful crisis (vaso-occlusive crisis) or acute chest syndrome
- You are receiving morphine through a PCA pump for pain control
- You agree to take part in the study, or a family member can consent for you if you are unable
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests whether giving high-flow oxygen can help treat a painful sickle cell “vaso-occlusive crisis” (VOC) and lower the risk of a serious lung complication. You may be eligible if you’re an adult with sickle cell disease experiencing an opioid-requiring pain flare and have higher risk for lung trouble.
This trial tests a medicine called iloprost, given through an IV, to see if it can help relieve the pain of a sickle cell crisis. If you are hospitalized for a crisis, this treatment may speed up your recovery and reduce pain.
This trial compares different ways to manage sickle cell pain crises in the hospital, using a flexible 'platform' design to test combinations of pain medicines. It aims to find the safest and most effective approach to reduce pain and improve recovery.
This study tests whether a low-dose of ketamine (a pain medicine) can help children and young adults with sickle cell disease who are in a pain crisis. It aims to provide better pain relief while avoiding some side effects of standard painkillers.
This trial tests an intravenous medicine called L-citrulline for young people with sickle cell disease who are in the emergency department for a painful crisis (vaso-occlusive crisis). It aims to see if it can ease the pain and help you recover faster.
This trial tests if an intravenous medication called L-citrulline can help treat pain crises in children and young adults with sickle cell disease. Participants receive either the study drug or a placebo while in the hospital for a severe pain episode.
Hear when a new Sickle Cell Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.