Pain relief pill before knee replacement surgery
Part of Pain clinical trials.
This study tests whether a natural supplement called palmitoylethanolamide (PEA) can help reduce pain after knee replacement surgery when taken before the operation. It may offer better pain relief with fewer side effects compared to standard care.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 40 and 80 years old.
- You are scheduled for a total knee replacement.
- You do not have rheumatoid arthritis.
- You have no history of kidney problems.
- You have not had complications from previous knee surgeries (like fractures or the need for special implants).
- You are willing to participate.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This Phase 2 study compares two ways to reduce pain after total knee replacement (TKA): a steroid-enhanced nerve block versus a numbing shot called Exparel. It aims to see which option improves comfort and recovery after surgery done with spinal anesthesia.
This Phase 2 study compares two ways of reducing nerve pain after knee replacement surgery (total knee arthroplasty). It looks at whether steroid-enhanced pain medicine works better than a different numbing injection to improve recovery and comfort.
This study tests whether giving two pain medicines before knee replacement surgery reduces pain after the operation. The medicines are ketorolac (an anti-inflammatory) and gabapentin (a nerve pain medicine).
This study tests if a long-lasting numbing medicine called Exparel, given by the surgeon during knee replacement, helps control pain after surgery. It is for people having their first total knee replacement on one knee due to arthritis.
This study compares different ways to manage pain after a first total knee replacement. It looks at how much pain medicine you need and how well you recover after surgery, to find the best way to reduce pain and improve your recovery.
This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.
Hear when a new Total Knee Replacement trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.