Stenting plus heart drugs vs. drugs alone for weak heart muscle
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests whether adding stenting to standard heart failure medications can improve outcomes for people with a weak heart pump (ejection fraction 40% or less) and blocked arteries. It compares the combination of heart drugs plus stenting to heart drugs alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older.
- Your heart's pumping strength (ejection fraction) is 40% or less, measured by an ultrasound within the last 3 months.
- You have symptoms of heart failure (like shortness of breath or fatigue) or have been hospitalized for it in the past year, or a blood test shows high NT-proBNP (≥600).
- You have at least one narrowed or blocked heart artery that a doctor thinks can be treated with a stent.
- You have been on stable heart failure medications for at least 4 weeks.
- You are not currently having severe angina (chest pain) that needs emergency stenting or bypass surgery.
- You have not had a stent placed in the last 12 months or bypass surgery ever.
- You are not pregnant or planning to become pregnant, and are using effective birth control if applicable.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at whether opening blocked heart arteries with a stent (a PCI procedure) works better than staying on heart medicines for people with weakened pumping function and certain types of heart failure. It may help patients by testing which approach best improves outcomes over time.
This study compares two ways to improve blood flow in people with weakened heart pumping (ischemic cardiomyopathy): bypass surgery (CABG) versus stent treatment (PCI). It aims to see which approach works better when the heart still has enough at-risk muscle and when best medical therapy is already started.
This study compares two ways to restore blood flow to the heart—bypass surgery (CABG) or stent procedure (PCI)—in people with a weak pumping heart. It looks at which approach works best when the heart muscle is not pumping well and there are multiple blocked heart arteries.
This trial compares two ways to restore blood flow to the heart—bypass surgery (CABG) or stents (PCI)—in people whose heart pumps weakly (LVEF 40% or less). It aims to find which method works better for chest pain or recent heart issues.
This trial tests whether placing stents in coronary arteries helps patients with heart failure who still have a strong-pumping heart. The study aims to see if improving blood flow to the heart reduces symptoms and improves quality of life.
This study looks at treatment options for adults with significantly reduced heart pumping strength and extensive coronary artery disease. It may help people who are at higher risk due to widespread blocked heart arteries, but eligibility depends on recent heart events and bleeding risk.
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