Treatment
Guideline Directed Medical Therapy clinical trials
We’re tracking 57 recruiting studies that include Guideline Directed Medical Therapy, each written for real people, not researchers, below.
Recruiting studies
- NCT07295522RecruitingPhase 4
Medication adjustments for women after heart failure hospitalization
This trial tests whether adjusting heart failure medications in women can improve their recovery and outcomes. It focuses on women who have been recently hospitalized for acute heart failure and are not yet on optimal medication doses.
San Donato Milanese, MILANOAges 18–85 - NCT06365502Recruiting
Preventing future heart attacks with drug-coated balloon
This trial tests whether a balloon coated with medicine (drug-coated balloon) can prevent future heart attacks by treating high-risk plaques in arteries that are not the one that caused your current heart attack. You may qualify if you already had a stent placed and have another mildly blocked artery with certain vulnerable features.
Beijin, Beijing MunicipalityAges 18–80 - NCT07820410RecruitingPhase 2/Phase 3
Atrial shunt for heart failure with reduced pumping function
This study tests a small device that creates a tiny opening inside the heart to help lower pressure and improve symptoms in people with heart failure. The procedure is minimally invasive and aims to reduce hospitalizations and improve quality of life.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07709208Recruiting
Mitral valve repair for leak that worsens with exercise
This trial tests a procedure to fix a leaky mitral valve that only becomes severe during exercise. It may help people with symptoms like shortness of breath or fatigue who haven't responded to standard heart medications.
DüsseldorfAges 18 years+ - NCT07631156RecruitingPhase 4
Safely Reducing Heart Failure Medications After Recovery
This study tests whether patients whose heart function has fully recovered after surgery or a heart procedure can safely reduce or stop their heart failure medications. Researchers will carefully monitor whether gradually lowering these medicines is safe and maintains heart health.
Daegu, DaeguAges 19 years+ - NCT07560982Recruiting
Improving medication adherence in advanced heart failure
This study looks at whether patients with severe heart failure follow their prescribed medications as recommended by treatment guidelines. The researchers want to understand what helps or prevents patients from taking their medicines correctly, which could improve their heart function and symptoms.
BergamoAges 18–75 - NCT07513883RecruitingPhase 4
Reducing Heart Failure Medications When Your Heart Recovers
This study tests whether patients whose heart failure has improved can safely reduce some of their medications. If your heart function has recovered significantly and stayed stable, this trial explores whether you can gradually lower doses of heart failure drugs while staying healthy.
GenkAges 18 years+ - NCT05845424RecruitingPhase 4
High-intensity cholesterol pills for people with silent calcium
This trial studies whether high-intensity statin plus ezetimibe can improve heart health in people who do not have symptoms but have calcium buildup in their heart arteries. It may help lower cholesterol and reduce future heart risks for the right participants.
SeoulAges 40 years+ - NCT07433504Recruiting
Tricuspid valve clipping for leaky valve
This trial tests a new device that clips the tricuspid valve to stop blood from flowing backward. It is for people with severe tricuspid regurgitation (a leaky valve) who still have symptoms despite medical treatment.
ShanghaiAges 18 years+ - NCT07414225Recruiting
MitraClip procedure for atrial functional mitral regurgitation
This trial tests a minimally invasive procedure to repair a leaky mitral valve in people with a specific type of heart failure. The goal is to see if the procedure, called transcatheter edge-to-edge repair (TEER), is safe and effective in reducing symptoms and improving heart function.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07405944RecruitingPhase 4
Vericiguat for improving heart function in heart failure
This study tests a medicine called vericiguat (a pill) to see if it can improve the heart's shape and function in people with heart failure and a weakened pump. You would keep taking your usual heart medications plus the study drug.
IzolaAges 18 years+ - NCT07352891Recruiting
Digital remote management vs. usual care for heart failure
This trial tests whether using a remote monitoring platform to help manage medications improves outcomes in people with heart failure and reduced pumping function. It compares this approach to standard follow-up care.
BeijingAges 18 years+ - NCT07355023Recruiting
AI ECG to guide heart medication for normal pump function
This study uses an AI-enhanced ECG to guide doctors in prescribing heart medications and aims to prevent future heart-pumping problems. It may help you if your heart function is currently normal and you have recent heart tests.
Taipei, TaipeiAges 18 years+ - NCT07349875RecruitingPhase 4
Colchicine for non-severe coronary plaque: a trial
This trial tests if the anti-inflammatory drug colchicine can help people with non-severe coronary artery plaque seen on a CT scan. It may be an option if you have stable chest pain or related symptoms and your heart arteries are partly blocked but not severely.
NanjingAges 18 years+ - NCT07107971Recruiting
Drug balloon vs. standard care for fatty heart plaques
This study compares a drug-coated balloon (which releases medicine into the artery) with standard medicines alone for treating fatty plaques in the heart arteries. It is for people who have already had a heart attack and a successful opening of a blocked artery.
AmsterdamAges 18 years+ - NCT07068490Recruiting
Potassium blocker study for heart stent patients
This study looks at whether a type of stomach acid medication called PCAB can help people who have had a heart stent and take blood thinners. It checks if PCAB is safe and reduces stomach bleeding.
SeoulAges 18 years+ - NCT07071038RecruitingPhase 2
Switching medication to relieve side effects from aromatase inhibitors
This trial tests whether switching to a different aromatase inhibitor or using standard treatments works better for managing side effects in breast cancer survivors. It aims to help you stay on hormone therapy longer with fewer discomforts.
Lebanon, New HampshireAges 18 years+ - NCT06965504Recruiting
Heart failure medications with an Impella heart pump for cardiogenic shock
This study tests whether a special heart pump (Impella 5.5) can help patients with severe heart failure (cardiogenic shock) safely start and increase their heart failure medications. The goal is to see if this approach can help the heart recover and improve outcomes.
Tampa, FloridaAges 18–80 - NCT06942221Recruiting
Digital Heart Failure Support After Hospital Stay
This trial tests a digital health tool to help manage heart failure medications after you leave the hospital. If you were recently hospitalized for heart failure and have a smartphone or tablet, you may be able to join.
BaselAges 18 years+ - NCT06580392Recruiting
CCM device plus medications for heart failure with low pump strength
This study tests a heart device (CCM) plus standard medications to see if the combination helps people with a weak heart pump. It's for those whose heart function is low and who still have symptoms despite current treatment.
Rome, ItalyAges 18 years+ - NCT06526195Recruiting
A study of CardioMEMS and HeartMate 3 for advanced heart failure
This trial tests if a combination of a tiny lung-artery pressure sensor (CardioMEMS) and a mechanical heart pump (HeartMate 3) is safe and effective for people with advanced heart failure. If you qualify, you'll either get the heart pump plus standard medical therapy, or continue with standard therapy alone and have your pressure monitored remotely.
Phoenix, ArizonaAges 18 years+ - NCT06087029Recruiting
Improving outcomes in aortic dissection
This study tests a minimally invasive procedure called TEVAR to repair a type B aortic dissection (a tear in the wall of the main artery from your heart). It may help prevent further damage and improve recovery.
Birmingham, AlabamaAges 21 years+ - NCT05865600Recruiting
PET/CT guided planning for treatment in chronic coronary disease
This trial uses a heart scan (PET/CT) to better estimate blood flow in people with long-term coronary artery disease. It aims to help doctors choose the best treatment strategy and decide who may need more invasive testing or procedures.
Herning, Central JutlandAges 18 years+ - NCT05180773RecruitingPhase 4
Bromocriptine for new postpartum heart weakness
This trial studies whether bromocriptine improves health outcomes in people recently diagnosed with peripartum cardiomyopathy (a weakened heart during late pregnancy or soon after delivery). You may be asked about timing after childbirth, heart strength tests, and whether you plan to keep breastfeeding.
Birmingham, AlabamaAges 18 years+
What Guideline Directed Medical Therapy is being studied for
Conditions with recruiting Guideline Directed Medical Therapy studies.
Common questions
- Are there clinical trials studying Guideline Directed Medical Therapy?
- Yes. Clin2 currently lists 57 recruiting studies that include Guideline Directed Medical Therapy, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Guideline Directed Medical Therapy trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Guideline Directed Medical Therapy an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Guideline Directed Medical Therapy or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.