Ketogenic diet and brain stimulation for hard-to-treat depression
Part of Mental health clinical trials.
This study tests whether a ketogenic diet combined with a brain stimulation technique called neuromodulation can help people with treatment-resistant depression feel better. You will be assigned to follow either a ketogenic diet or a standard diet for 12 weeks while receiving the treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You are currently in a moderate to severe major depressive episode and have not responded well to at least 2 different antidepressants (or couldn't tolerate them).
- You have not had a treatment called rTMS during this episode, and you have not failed ECT (electroconvulsive therapy) in this episode.
- You are willing to follow either a high-fat, low-carb ketogenic diet or a standard Canadian diet for 12 weeks, and you can do daily finger-stick blood tests.
- You have no major medical conditions like epilepsy, stroke, or a history of seizure, eating disorder, or pregnancy.
- You are not currently on a low-carb or ketogenic diet, and you do not have food allergies or gut problems that would interfere with the study diets.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a new type of brain stimulation called theta-burst stimulation to see if it helps treat depression. It is for people aged 18-50 who are currently experiencing a major depressive episode and are on a stable antidepressant regimen.
This study looks at whether certain substances in the blood can help predict how well a type of brain stimulation called intermittent theta burst stimulation (iTBS) works for people whose depression hasn't improved with standard treatments. It may help doctors choose better treatments in the future.
This study tests an accelerated form of iTBS (a non-invasive brain stimulation technique) for depression that hasn't improved with antidepressant medications. The goal is to help people with major depression who haven't responded adequately to at least one antidepressant drug.
This trial tests if doing exercise before repetitive transcranial magnetic stimulation (rTMS) can improve depression symptoms in people who haven't gotten better with standard treatments.
This trial tests a personalized brain stimulation method called neuronavigated aiTBS for people with depression that hasn't improved with at least two prior treatments. The goal is to see if this therapy can safely and effectively reduce depressive symptoms.
This study tests a personalized type of brain stimulation, called iTBS, for people with depression. It aims to see if tailoring the treatment to each person's brain activity makes it more effective.
Hear when a new Major Depressive Disorder (MDD) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.