Ketogenic diet and brain stimulation for hard-to-treat depression
Part of Mental health clinical trials.
This study tests whether a ketogenic diet (a low-carb, high-fat eating plan) combined with a type of brain stimulation called rTMS can help people whose depression hasn't improved with standard treatments. You'd be randomly assigned to follow either the ketogenic diet or a standard healthy diet for 12 weeks.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 65 years old.
- You are currently experiencing a major depressive episode and have moderate or worse symptoms (PHQ score of 10 or more).
- You have tried at least two antidepressant treatments that didn't work or caused intolerable side effects.
- You haven't had rTMS in this current episode, and you haven't failed ECT in this episode.
- You can commit to a 12-week diet plan and are willing to do daily finger-prick blood tests.
- You are not pregnant, nursing, or planning to become pregnant, and you have no active eating disorder or serious unstable medical illness.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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