Heart support medication for newborns with brain injury
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests whether adding a medication called dobutamine, which helps the heart pump, can improve recovery in newborns with HIE who are already receiving cooling treatment. It aims to see if this extra heart support can help babies recover better.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your baby must have hypoxic-ischemic encephalopathy (HIE), which is a brain injury caused by low oxygen, and must already be receiving cooling treatment (therapeutic hypothermia).
- Your baby must not have any birth defects or congenital abnormalities.
- Your baby must not have any condition that would make the medication dobutamine unsafe, like a heart outflow blockage, an allergy to dobutamine, or a fast irregular heart rhythm.
- Your baby must not already be on other heart-supporting medications (inotropes) when the trial begins.
- You, as the parent or guardian, must give permission for your baby to join the trial.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This trial studies whether cooling a newborn's body after a difficult birth helps prevent brain damage. Researchers will track babies treated with this cooling therapy and use brain imaging to see how well it works.
This trial tests if giving caffeine to newborns who had low oxygen at birth can help protect their brains. It compares caffeine plus standard care to placebo plus standard care for moderate to severe hypoxic ischemic encephalopathy (HIE).
This study uses whole genome sequencing to look at the genes of newborns with HIE (brain injury from lack of oxygen) who are receiving cooling treatment. The goal is to learn more about how genes may affect recovery and outcomes.
This study tests whether adding a medication called sildenafil (commonly used for blood pressure) to standard cooling treatment can improve brain recovery in newborn babies with brain injury from lack of oxygen. It aims to see if the combination is safe and effective in helping these babies develop better.
This trial is for newborn babies who had an oxygen shortage around birth and now have severe brain injury. It aims to test approaches that may help improve outcomes after this kind of early-life brain damage.
This study compares different approaches to “cooling” treatment in newborns with mild hypoxic-ischemic encephalopathy (mild brain injury from not enough oxygen around birth). The goal is to see which approach works best and is safest for babies like yours.
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