Protect-HIE pilot trial for newborns with HIE
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests if adding a heart medication called dobutamine to standard cooling therapy helps newborns with HIE (brain injury from lack of oxygen at birth). It aims to protect the heart and brain during treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your newborn has HIE (brain injury due to low oxygen at birth)
- Your newborn is receiving cooling therapy to lower body temperature
- Your newborn does not have a serious birth defect
- Your newborn has not already started other heart medications
- Your newborn does not have a heart condition that dobutamine could worsen
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial is testing a treatment for newborns who had low oxygen around birth, leading to brain injury. It may help babies who did not get certain medicines before birth.
This study uses whole genome sequencing to look at the genes of newborns with HIE (brain injury from lack of oxygen) who are receiving cooling treatment. The goal is to learn more about how genes may affect recovery and outcomes.
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This trial studies whether RLS-0071 is safe and can help some newborns with moderate or severe hypoxic-ischemic encephalopathy (HIE), a brain injury caused by low oxygen around birth. Babies in the study also receive standard whole-body cooling (therapeutic hypothermia), and the researchers will watch for side effects and early signs of benefit.
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