Testing a higher pacemaker lower rate for ATTR cardiac amyloidosis
Part of Brain & nervous system, Genetic & congenital, Hormones & metabolism clinical trials.
This trial tests whether setting your pacemaker to a slightly faster minimum heart rate (the 'lower rate') can improve your heart function and symptoms. It might help by making your heart beat more efficiently, potentially reducing fatigue and shortness of breath.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with ATTR-CM, a type of heart condition caused by abnormal protein buildup in the heart.
- You are either on a treatment that stabilizes or lowers the abnormal protein, or your doctor has said these treatments are not suitable for you.
- You have a pacemaker already, and your heartbeat is mostly controlled by it (more than 80% of the time).
- Your heart function is in a moderate stage (NYHA class II or III), meaning you have some limitation in physical activity but not severe.
- A blood test shows your NT-proBNP level is above 600, indicating the heart is under strain.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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