Clin2
NCT07413627Possibly a fitNot yet recruiting

Reducing side effects of radiation therapy for mouth and throat cancer

Squamous Cell Carcinoma of the Oral Cavity and Oropharynx

Part of Cancer, Ear, nose & throat, Mouth & dental clinical trials.

This study tests whether a newer radiation therapy technique, using non-coplanar beams, can reduce side effects like dry mouth and throat pain in people with mouth or throat cancer. You may be able to join if you are getting radiation therapy to both sides of the neck and have not had surgery for this cancer.

Summary written for real people, not researchers, by Clin2.

Phase
N/A
Enrollment
70 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older.
  • You have a confirmed diagnosis of squamous cell carcinoma of the mouth or the back of the throat (oropharynx), which has not been surgically removed and has not spread to other parts of the body.
  • You are scheduled to receive radiation therapy to both sides of the neck (bilateral) with or without chemotherapy, as part of your treatment plan.
  • You are planned to receive standard photobiomodulation (a type of light therapy) during your radiation treatment.
  • You are generally able to carry out daily activities (performance status 0, 1, or 2 on the ECOG scale).
  • You do not have significant dry mouth at the start of the study (less than grade 1 on the CTCAE scale).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07058805Recruiting· Phase 2
Radiation therapy after surgery for head and neck cancer

This trial tests whether giving radiation therapy in a specific way (compartmentalized) after surgery for head and neck cancer is safe and effective. It is for people with certain types of head and neck cancer that have been removed, and aims to improve outcomes while managing side effects.

Basel
NCT06282497Recruiting
New radiation technique to reduce dry mouth in nasopharyngeal cancer

This trial compares a new radiation technique designed to reduce dry mouth (xerostomia) with standard radiation for people with nasopharyngeal cancer. It aims to see if the new approach can protect saliva glands while still treating the cancer effectively.

Zhongshan, Guangdong
NCT06353685Recruiting· Phase 2
Less radiation after surgery for oral cancer with good response

This trial is testing whether giving less radiation after surgery is safe and effective for people with oral cancer whose surgery results were very good (no cancer cells or very few left). It aims to reduce side effects while still preventing cancer from coming back.

Guangzhou
NCT06861712Not yet recruiting· Phase 2
Chemoimmunotherapy with or without radiation before surgery for advanced mouth and throat cancer

This trial tests whether adding a type of radiation therapy (SBRT) to chemoimmunotherapy before surgery helps people with advanced mouth or throat cancer. The goal is to see if this combination can shrink tumors more effectively and improve outcomes.

Guangzhou, Guangdong
NCT05674396Recruiting· Phase 2
Short-course radiation to ease symptoms from head and neck cancer

This Phase 2 trial tests a specific, shorter type of focused radiation to help relieve symptoms from head and neck squamous cell carcinoma. It compares two radiation timing/planning approaches to see which better improves comfort and quality of life.

Houston, Texas
NCT05187091Recruiting· Phase 3
Radiation plan that tries to protect swallowing organs

This Phase 3 study compares a standard radiation approach versus a modified approach designed to spare key swallowing and aspiration (choking) related areas and one salivary gland. It may help reduce treatment side effects that affect swallowing and quality of life for certain head and neck cancer patients.

Jhajjar, Haryana

Hear when a new Squamous Cell Carcinoma of the Oral Cavity and Oropharynx trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.