Trastuzumab Deruxtecan for HER2-mutant lung cancer before surgery
Treatments studied
Part of Cancer, Lungs & breathing clinical trials.
This trial tests a targeted drug, trastuzumab deruxtecan, for people with non-small cell lung cancer that has a specific HER2 gene change. The treatment is given before surgery to shrink the tumor and make it easier to remove.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have non-small cell lung cancer that has spread to nearby lymph nodes but not to distant parts of the body.
- Your tumor must have a specific change in the HER2 gene, found through a blood or tissue test.
- You must be healthy enough for lung surgery, with good lung and heart function.
- You cannot have had any prior treatment for lung cancer within the last 3 years.
- You must not have a history of lung inflammation (interstitial lung disease) or other serious lung conditions.
- You must agree to use effective birth control during and for several months after treatment.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This trial compares giving trastuzumab-deruxtecan before surgery versus standard chemotherapy plus trastuzumab and pertuzumab. It aims to see which approach works better to shrink or control HER2-positive early breast cancer and improve outcomes.
This trial tests a targeted drug called trastuzumab deruxtecan in people with advanced non-small cell lung cancer that has high levels of a protein called HER2. It may be an option if your cancer has grown after at least one prior treatment.
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