Testing a clot-busting drug for wake-up strokes without advanced scans
Treatments studied
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests if the clot-busting drug tenecteplase can help people who have a stroke with an unknown start time (like waking up with symptoms) and cannot get an advanced brain scan. It aims to see if treatment within 3 hours of noticing symptoms is safe and effective.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have had a stroke that started at an unknown time (e.g., woke up with symptoms), and it has been more than 4.5 hours since you were last known to be normal.
- You can start treatment within 3 hours of noticing your stroke symptoms.
- Your stroke symptoms are moderate to moderately severe, as measured by a standard stroke scale (NIHSS score 6-25).
- You were able to walk and take care of yourself before the stroke (mRS score 0-1).
- You do not have a bleeding problem, recent major surgery, or other serious medical conditions that would increase risk.
- You are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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