Clin2
NCT07509645Likely a fitRecruiting

Testing a new drug with clot removal for severe back-of-the-brain stroke

Ischemic Stroke

Treatments studied

Part of Brain & nervous system, Heart & circulation clinical trials.

This trial checks if adding an interleukin-6 receptor inhibitor (a drug that reduces inflammation) to standard emergency clot removal can improve recovery for people with a severe stroke affecting the back part of the brain (posterior circulation). It is for patients who need urgent treatment within 24 hours of symptom onset.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
348 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You are 18 years or older
  • You had a sudden blockage of the main artery in the back part of your brain (basilar artery)
  • Your stroke is severe enough that you have a score of 10 or higher on the NIH stroke scale
  • You are able to start the clot-removal procedure within 24 hours of the first symptoms
  • You do not have a bleeding disorder, active infection, or known allergies to the study drug or contrast dye
  • You are not pregnant or planning pregnancy in the next 90 days

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06447701Not yet recruiting· Phase 3
Anti-inflammatory drug for narrowing arteries in the brain

This trial tests whether a drug that lowers inflammation can reduce the risk of another stroke in people with narrowing of a brain artery. The treatment is given after a mild stroke or mini-stroke.

NCT06712004Recruiting· Phase 2
Testing a new stroke drug: different doses for people who cannot get standard care

This trial tests a new medication (bevifibatide) to see which dose works best for people having an ischemic stroke who cannot get standard treatments like clot-busting drugs or a procedure to remove the clot. It aims to improve recovery by stopping clots from getting worse.

Guangzhou, Guangdong
NCT06949228Recruiting· Phase 2/Phase 3
Intra-Arterial Tenecteplase After Clot Removal for Stroke

This trial tests whether giving a clot-busting drug called tenecteplase directly into the brain artery after a successful mechanical clot removal can improve recovery for people with a certain type of stroke. The goal is to see if it safely helps clear any remaining tiny clots and reduces disability.

Toledo, Ohio
NCT06788626Not yet recruiting· Phase 3
Testing a medication after clot removal for major stroke

This study tests whether a medication called a GLP-1 receptor agonist (a type of drug used for diabetes) can improve recovery after a major stroke that was treated with a procedure to remove the blood clot. The goal is to see if this drug helps reduce further brain damage and improve outcomes.

Hefei, Anhui
NCT07870681Not yet recruiting· Phase 2/Phase 3
Tocilizumab for acute ischemic stroke after clot removal

This trial studies whether giving an anti-inflammatory drug called tocilizumab after emergency clot removal improves recovery from a severe stroke caused by a blocked artery in the brain.

Aalborg
NCT07801638Recruiting
Anticoagulation plus tocilizumab for cerebral venous thrombosis

This trial tests a combination of blood thinners (anticoagulation) and a drug called tocilizumab, which targets inflammation, to treat acute cerebral venous thrombosis (a blood clot in a vein in the brain). It aims to see if this combined treatment improves recovery and reduces complications compared to blood thinners alone.

Beijing, Beijing Municipality

Hear when a new Ischemic Stroke trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.