Mast cell treatments for post-tick bite illness
Treatments studied
Part of Immune system & allergy, Infections clinical trials.
This study tests whether two oral medications (ketotifen and cromolyn) can help reduce symptoms in people who have ongoing problems after a tick bite illness or alpha-gal syndrome. These medicines may calm overactive mast cells, which are immune cells that can cause symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 21 and 65 years old.
- You were diagnosed with a tick-borne illness (like ehrlichiosis or Rocky Mountain spotted fever) or alpha-gal syndrome (a meat allergy from tick bites) within the last 3 years, and you were treated more than 6 months ago.
- You still have symptoms that cause distress or affect your daily life.
- If you are a woman who can get pregnant, you must have a negative pregnancy test and be willing to avoid pregnancy during the study.
- You must be able to stop taking Benadryl (diphenhydramine) during the study.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study looks at how the body reacts to tick bites, specifically to understand alpha-gal syndrome—a condition that can cause allergic reactions to red meat. If you had a recent tick bite and can provide the tick, you may be able to help researchers learn more.
This study looks at how your body's immune system reacts to a tick bite. It may help doctors understand and prevent tick-borne diseases, which are illnesses spread by ticks, like Lyme disease.
This trial collects blood and tissue samples to better understand allergies, asthma, and mast cell conditions. It aims to find markers that could improve diagnosis and treatment. Participation involves donating samples and sharing medical history.
This study looks at IgE, a protein involved in allergic reactions, to better understand its role in different immune-related diseases. It aims to find out how different forms of IgE relate to health and disease, which may help improve diagnosis or treatment.
This study tests whether a steroid medication called dexamethasone can help people with tick-borne encephalitis, a serious brain infection spread by ticks. The goal is to see if this treatment reduces inflammation in the brain and improves recovery.
This study looks for a specific gene change (KIT D816V) in people with certain allergic reactions or related conditions. It aims to find those who might benefit from future treatments targeting this mutation.
Hear when a new Post-tick Bite Illness trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.