Colchicine to prevent amputation after leg artery treatment
Treatments studied
Part of Heart & circulation clinical trials.
This study tests whether a medication called colchicine can help prevent amputation in people with severe leg blood flow problems who just had surgery or a catheter procedure to restore blood flow. Colchicine is an anti-inflammatory drug that may help protect the leg tissue after treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have severe leg circulation problems (pain at rest, non-healing wounds, or gangrene) confirmed by imaging and blood pressure measurements in your legs
- You had successful surgery or catheter procedure to restore blood flow to your leg within the past 7 days
- Blood flow to your foot has been restored after the procedure with at least one artery open
- You are willing and able to attend follow-up visits and take study medication as directed
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This study tests a new way to restore blood flow in the lower leg for people with chronic limb-threatening ischemia, a serious condition where leg wounds won't heal due to poor circulation. If it works, this treatment could help save the leg and avoid amputation.
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This trial tests whether low-dose colchicine can reduce “residual” risk—future heart and blood-vessel problems—in people with peripheral artery disease (PAD). It targets PAD symptoms and complications like poor blood flow in the legs, even after certain procedures.
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This trial tests how long patients should take two blood-thinning medications (aspirin and clopidogrel) after treatment to restore blood flow to a severely damaged leg. The goal is to find the right balance between preventing clots and avoiding dangerous bleeding.
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