Dexmedetomidine for Hard-to-Treat Septic Shock
Treatments studied
Part of Heart & circulation, Infections clinical trials.
This trial tests whether a medication called dexmedetomidine can help patients with severe, treatment-resistant septic shock (a life-threatening blood infection) who aren't responding well to standard treatments. The goal is to see if it improves survival and organ function.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have septic shock (severe infection with very low blood pressure requiring medications to maintain adequate perfusion) and high lactate levels (a sign your body isn't getting enough oxygen)
- Your blood pressure is not responding well to high doses of standard blood-pressure medications (norepinephrine), and you show signs of circulatory failure
- You've received adequate IV fluids and are on a mechanical ventilator (breathing machine)
- You do not have severe liver damage, a very slow heartbeat, or a serious heart conduction problem
- You are not pregnant, breastfeeding, or enrolled in another competing clinical trial
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
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This trial tests if the drug dexmedetomidine can help calm the stress response in people with severe infection-related shock. It compares this approach with standard care to see if it improves outcomes for patients in the intensive care unit.
This study tests whether adding a sedative called dexmedetomidine, along with your current care, can improve blood flow in small blood vessels under the tongue for people with septic shock in the ICU.
This trial tests if dexmedetomidine, a sedative, can help protect the kidneys of critically ill patients with sepsis who develop acute kidney injury (a sudden drop in kidney function). It is for adults in the ICU who need a breathing tube or mask within 48 hours of kidney injury.
This study tests a non-invasive, goal-based treatment approach for people with septic shock—an emergency condition caused by severe infection. It may help by using blood-pressure and circulation targets to guide care without more invasive procedures.
This trial tests whether adding vasopressin (a drug that helps raise blood pressure) to standard treatment can help people with septic shock. It is for adults who already need a high dose of another blood pressure medicine called noradrenaline.
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