Two drugs combined to treat Cushing's disease
Treatments studied
Part of Brain & nervous system, Genetic & congenital, Heart & circulation, Hormones & metabolism, Kidney & urinary, Women’s health & pregnancy clinical trials.
This trial tests whether taking two medications together—osilodrostat and cabergoline—can help control Cushing's disease by lowering excess cortisol levels. Cushing's disease is caused by a pituitary tumor that makes too much of a hormone called ACTH, which drives cortisol overproduction.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have Cushing's disease that is either untreated or has been treated with surgery and/or radiation
- Your Cushing's disease is currently active (confirmed by two separate blood and saliva cortisol tests)
- Blood tests show you have elevated ACTH hormone levels
- A special hormone stimulation test (desmopressin) shows your pituitary responds abnormally
- An MRI scan shows you have a pituitary tumor (adenoma)
- You do not have severe liver damage and are not pregnant
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
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This study tests a drug called osilodrostat (a pill) to see if it can lower blood pressure in people with Cushing's syndrome. If you have Cushing's and your blood pressure is still high despite medication, this trial might help you find better control.
This Phase 2 study tests how osilodrostat works in children and teens with Cushing’s syndrome—what the drug does in the body, how it affects hormones, and how safely it’s tolerated. It may help families who cannot have immediate surgery or whose surgery has already failed or is still pending.
This study tests whether a combination of a drug called osilodrostat (which lowers cortisol levels) and a special PET scan can help find small pituitary tumors that MRI misses. This may help guide surgery or treatment for Cushing's disease.
This Phase 2 trial tests fimepinostat (a targeted cancer-style drug) to help control Cushing disease caused by a pituitary tumor. It’s mainly for adults whose Cushing is confirmed to come from the pituitary and who meet safety and medication-washout rules.
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