Brain Protection Device During Aortic Valve Replacement
Part of Brain & nervous system, Heart & circulation clinical trials.
This trial tests a new device called CHORDS that protects your brain during transcatheter aortic valve replacement (TAVR), a minimally invasive procedure to fix a narrow aortic valve. The device works by blocking debris that might travel to your brain during the procedure.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have severe aortic stenosis (narrowing of the aortic valve) causing symptoms and are scheduled for TAVR
- Your carotid and brachiocephalic arteries (major neck blood vessels) are the right size (6.5–10 mm and 9–15 mm) with no significant blockages
- You are at least 18 years old and able to understand the study and consent to participate
- You do not have contraindications to blood thinners, contrast dye, or the nitinol metal used in the device
- You have not had a recent heart attack (within 30 days) and do not have existing blood clots or infections in the heart
- You are able to undergo required imaging (MRI) and clinical follow-up visits
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
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This study tests if a special device placed during transcatheter aortic valve replacement (TAVR) can help prevent stroke. It is for adults with severe aortic stenosis who are already scheduled for TAVR.
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This study tests a special protection device used during a heart procedure (called M-TEER) that repairs a leaky mitral valve. The device is designed to catch any small debris or blood clots that might break loose during the procedure, reducing the risk of a stroke or brain injury.
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