Clin2
NCT07655362Possibly a fitNot yet recruiting

Baxdrostat for heart muscle thickening

Cardiac Remodeling

Treatments studied

Part of Heart & circulation clinical trials.

This trial tests a new medication called baxdrostat that may help reduce thickening of the heart's main pumping chamber (left ventricular hypertrophy), which is often caused by high blood pressure. The study will see if this drug helps improve heart health in people with this condition.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 3
Enrollment
286 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must be at least 18 years old.
  • You need to have high blood pressure, with your systolic (top) number between 140 and 170.
  • A test must show that the muscle of your heart's main pumping chamber is thickened (called left ventricular hypertrophy).
  • You need to have at least one additional risk factor, such as diabetes, reduced kidney function, or evidence of heart strain.
  • You cannot have a pacemaker or implantable defibrillator, and you should not have had a recent heart attack or stroke.
  • You must be able to have an MRI scan of your heart (called cardiac MRI).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT07686120Recruiting· Phase 3
Baxdrostat for uncontrolled high blood pressure

This trial tests a new medicine called baxdrostat for people whose blood pressure stays high even when they take two or more medicines. It will be added to your current blood pressure pills to see if it helps lower your blood pressure more.

Beijing
NCT06742723Recruiting· Phase 3
Study of baxdrostat and dapagliflozin for kidney disease and high blood pressure

This trial tests if combining baxdrostat with dapagliflozin helps protect kidney function and reduce heart risks in people with chronic kidney disease and high blood pressure. It's for adults who are already taking standard blood pressure medications.

Fairhope, Alabama
NCT06979362Recruiting· Phase 2
Testing a new medicine for heart failure with thickened heart muscle

This study tests an experimental medicine, CDR132L, to see if it can improve heart structure and function in people with a type of heart failure where the heart muscle is thickened. If you have heart failure with normal pumping function and thickened heart walls, this trial may offer access to a new potential treatment.

Birmingham, Alabama
NCT06677060Recruiting· Phase 3
Study of baxdrostat plus dapagliflozin for heart risk in type 2 diabetes

This study tests whether a new drug called baxdrostat, when added to the diabetes medicine dapagliflozin (Farxiga), can prevent heart failure and heart-related death in people with type 2 diabetes, high blood pressure, and existing heart or blood vessel disease. You may be able to join if you have type 2 diabetes, heart or blood vessel disease, high blood pressure, and at least one extra risk factor for heart failure.

Birmingham, Alabama
NCT05569382Recruiting· Phase 4
Testing bisoprolol and verapamil in hypertrophic heart disease

This study tests whether two common heart medicines, bisoprolol and verapamil, improve symptoms in adults with non-obstructive hypertrophic cardiomyopathy. It may help you and your care team understand which medicine works better for symptom control and heart function.

Aarhus N
NCT07007793Recruiting· Phase 3
Study of baxdrostat for primary aldosteronism

This trial tests a new drug called baxdrostat for people with primary aldosteronism, a condition where the adrenal glands make too much aldosterone hormone, often causing high blood pressure. The goal is to see if baxdrostat helps control blood pressure and is safe.

Los Angeles, California

Hear when a new Cardiac Remodeling trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.