Blood pressure study: testing a new approach to first treatment
Treatments studied
Part of Heart & circulation, Hormones & metabolism clinical trials.
This study tests if measuring a blood protein called renin can help doctors choose the best first blood pressure medicine for you. It compares spironolactone to other common medicines like candesartan, hydrochlorothiazide, and amlodipine. This might help people with low renin levels get more effective treatment.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You are under the care of a family doctor in Ontario
- Your blood pressure is at least 130/80 mmHg (either at the doctor's office or on a 24-hour monitor)
- You are either not on blood pressure medicine, or taking only one medicine (ACE inhibitor, ARB, water pill, or calcium channel blocker) that your doctor says is safe to stop for 2 weeks
- Your renin level is low (less than 6 ng/L) from a routine blood test
- You do not have serious kidney disease or high potassium, and are not pregnant
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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This study is not testing a new medicine. Instead, it is using electronic health records to better understand people with high blood pressure, with a focus on those recently diagnosed. If you join, you may help researchers learn more about how to improve care for others with high blood pressure.
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