Finerenone vs spironolactone for high blood pressure from aldosteronism
Treatments studied
Part of Hormones & metabolism clinical trials.
This trial compares two medicines, finerenone and spironolactone, to see which works better and is safer for lowering blood pressure in people with primary aldosteronism. It may help you if you have high blood pressure caused by too much aldosterone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have high blood pressure (above 140/90) and have been diagnosed with primary aldosteronism.
- Your potassium level is at least 2.5, but no higher than 5 (based on a recent blood test).
- You do not have serious kidney disease (eGFR at least 60).
- You can avoid certain medications (like some antibiotics, antifungals, or seizure drugs) for 2 weeks before and during the trial.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a drug called finerenone for people with a specific cause of high blood pressure (primary aldosteronism). It aims to see if finerenone can help lower blood pressure and improve hormone levels better than current care.
This trial looks at whether adding spironolactone to your current blood pressure medicines works better for people with primary aldosteronism (a condition where your adrenal glands make too much aldosterone, raising blood pressure). You may qualify if you have this form of high blood pressure but have declined surgery or don't have an adenoma.
This study looks at how primary aldosteronism affects the heart and blood vessels, and whether blocking its hormone signal (with spironolactone or eplerenone) changes those findings on imaging tests. It is small and focuses on people with confirmed or suspected primary aldosteronism who are being followed for heart health.
This trial studies whether blocking part of the adrenal blood supply (“adrenal artery ablation”) along with spironolactone can improve hormone-driven high blood pressure caused by primary aldosteronism. It may help people who have confirmed adrenal overactivity and do not want surgery.
This trial studies whether a specific treatment (related to spironolactone/aldosterone support) can improve how well your blood vessels work in people with primary aldosteronism. It may help reduce blood pressure risk by improving blood vessel health.
This study tests whether adjusting a type of blood pressure medication (called a mineralocorticoid receptor antagonist) based on renin levels is safe and helpful for people with primary aldosteronism. It aims to find a better way to manage the condition.
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