Testing 3-drug combo for CLL/SLL patients
Treatments studied
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests a combination of three drugs (nemtabrutinib, venetoclax, and obinutuzumab) for people with CLL or SLL who need treatment but haven't taken similar targeted therapies before. It aims to see if this new cocktail works better together.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and have been diagnosed with CLL or SLL.
- Your doctor says it's time to start treatment (you meet guidelines to begin therapy).
- You have not taken a BTK inhibitor (like ibrutinib) or a BCL-2 inhibitor (like venetoclax) before.
- Your overall health is good enough to do daily activities (ECOG score 0-2).
- Your kidney and liver function are within safe limits (based on blood tests).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of two drugs (nemtabrutinib and venetoclax) to treat chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) in patients who have never received cancer treatment before. The goal is to see if this combination can shrink the cancer and help patients live longer.
This trial tests two different drug combinations (venetoclax with obinutuzumab or with acalabrutinib) to see how they affect the risk of tumor lysis syndrome in people with untreated CLL or SLL. It may help find the safest and most effective way to start treatment.
This trial tests a combination of three drugs (pirtobrutinib, venetoclax, and obinutuzumab) given for a limited time to people whose CLL/SLL has come back after prior treatment. The goal is to see if this combination can control the cancer and possibly allow a treatment-free period.
This trial tests a combination of three drugs (zanubrutinib, sonrotoclax, and obinutuzumab) for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have not had treatment before. The goal is to see if this combination works well and is safe.
This trial tests a new combination of three drugs for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have not had treatment yet. The goal is to see if this approach helps control the disease with fewer side effects.
This trial tests two different combinations of targeted drugs for people with CLL or SLL who have not had prior treatment for their disease. The goal is to see if these combinations are safe and effective.
Hear when a new Chronic Lymphocytic Leukemia trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.