Clinical trials
Periodontitis clinical trials
Below are recruiting periodontitis clinical trials, each written for real people, not researchers. We’re tracking 281 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07293962RecruitingPhase 2
Liquid S-PRF for gum disease treatment
This study tests whether a special liquid made from your own blood (called liquid S-PRF) can improve gum health during deep cleaning for people with advanced gum disease. It lasts 3 months and may help reduce inflammation and promote healing without surgery.
Jenjarum, SelangorAges 18–65 - NCT07254117Recruiting
Study on gum tissue healing for severe gum disease
This trial tests whether special granulation tissue can help regenerate bone and gum support in people with severe gum disease who still have deep bone pockets after initial treatment. It may offer a better way to heal these defects.
RigaAges Any age - NCT05533528Recruiting
Save gum tissue in surgery for severe periodontitis
This trial studies a way to preserve gum (periodontal) “granulation” tissue during surgical treatment for severe periodontitis (gum disease). It may help patients heal better after surgery, especially when deep gum pockets do not improve after non-surgical care.
MurciaAges 18 years+ - NCT06309719Recruiting
Hyaluronic acid and polynucleotides for gum disease treatment
This trial tests if a gel made from hyaluronic acid and polynucleotides can help repair gum damage in people with advanced gum disease. You may be eligible if you have deep pockets between your teeth and gums that haven't healed after standard cleaning.
LondonAges 18 years+ - NCT06522438Recruiting
Gel with Hyaluronic Acid for Gum Disease Treatment
This study tests whether a gel containing hyaluronic acid and octenidine can improve the results of standard deep cleaning for advanced gum disease. It may help reduce gum pocket depth and bleeding without the need for surgery.
LondonAges 18 years+ - NCT07443410Recruiting
Probiotics for gum disease treatment
This trial tests whether taking pre- and probiotics alongside non-surgical gum treatment improves healing and reduces harmful bacteria. It may help people with advanced gum disease (stage III or IV periodontitis).
Heidelberg, Baden-WurttembergAges 18 years+ - NCT05932017Enrolling by invitation
Compare two ways to see during gum surgery
This trial compares two tools surgeons use to see during gum (periodontal) surgery: magnifying loupes versus a videoscope. It may help improve how the procedure is done for people with more severe gum disease.
Dallas, TexasAges 18 years+ - NCT05858411Recruiting
Biologic gum treatments added to non-surgical cleaning
This trial studies whether adding a biologic medicine to standard non-surgical gum (periodontal) treatment can improve deep gum pockets in certain bone defects. It may help people whose gum disease has specific “intrabony” defects, but you must meet several health and medication rules.
TiranaAges 18 years+ - NCT06890676Recruiting
Dental care in nursing homes to prevent infections and improve health
This study tests whether bringing dental care to nursing home residents can reduce mouth infections, pneumonia, and help control blood sugar in people with diabetes. If you live in a nursing home and are 60 or older, you may be able to join.
Jefferson City, MissouriAges 60–100 - NCT06895980Recruiting
Gum treatment for better blood sugar in diabetes
This trial tests whether treating gum disease can help improve blood sugar control in people with type 2 diabetes. If you have poorly controlled diabetes and gum disease, you may be able to join this study.
Santiago, ProvidenciaAges 18 years+ - NCT07146776Recruiting
Injectable PRF and bone graft for gum disease bone defects
This trial tests a treatment for deep gum disease pockets using a combination of your own blood components (injectable platelet-rich fibrin) and a bone graft material. It aims to help regenerate bone lost to periodontitis.
Istanbul, ÜsküdarAges 18–65 - NCT07312552Recruiting
Gum health, smoking, and saliva markers study
This study looks at how gum health and smoking affect certain proteins in your saliva. It may help researchers understand more about gum disease and inflammation.
IstanbulAges 18–65 - NCT07316023RecruitingPhase 2
Light therapy for gum disease treatment
This trial tests a new light treatment for gum disease using a special dye that targets and kills harmful bacteria. It may help if you have advanced gum disease and haven't had treatment recently.
CairoAges 36–50 - NCT07410351Recruiting
Periodontal risk self-assessment for Saudi adults
This trial is creating a simple online tool to help you assess your risk for gum disease. If you join, you will answer a questionnaire and have a quick gum check at the same visit.
Abhā, 'Asir RegionAges 18 years+ - NCT07536204Recruiting
Gum Inflammation Study: Understanding Immune Cell Activation
This research study investigates how certain immune proteins (JAK1 and JAK2) work in gum tissue, both in healthy gums and in gum disease. Understanding this may help develop better treatments for periodontal disease in the future.
Santiago, Metropolitan RegionAges 18 years+ - NCT07574827Recruiting
Candida Fungus and Gum Disease in Syrian Patients
This study looks at whether a common fungus called Candida albicans is linked to chronic periodontitis (advanced gum disease). Researchers will examine gum samples from Syrian patients to understand this connection and may help improve gum disease treatment.
HomsAges 18 years+ - NCT07599657Recruiting
Protein Levels in Gum Disease Before and After Minimally Invasive Surgery
This study measures a natural protein in your gums before and after a minimally invasive surgical treatment for moderate to advanced gum disease. Researchers want to understand how this protein changes with treatment, which may help improve gum disease care in the future.
CairoAges 18 years+ - NCT07367737Enrolling by invitation
Comparing histatin-1 levels in smokers and non-smokers with gum disease
This study looks at a protein called histatin-1 in your saliva to see how it changes with gum disease treatment. Researchers want to compare levels between smokers and non-smokers before and after deep cleaning (a non-surgical treatment for periodontitis). It may help understand how smoking affects gum healing.
Baghdad, Medical CityAges Any age - NCT06929676Enrolling by invitation
Tooth mobility after gum disease treatment and splinting
This trial tests how much tooth movement improves after deep cleaning and splinting (connecting loose teeth) in people with advanced gum disease. It may help if you have loose front teeth from gum disease.
Piracicaba, São PauloAges 18 years+ - NCT05813236Recruiting
Compare two suture types for gum surgery healing
This trial compares two different types of stitches (suture materials) to see which one works better after gum (periodontal) surgery. It may help by improving comfort and healing in people needing resective periodontal surgery.
Sant Cugat del Vallès, CataloniaAges 18 years+ - NCT07707063RecruitingPhase 4
Gum disease treatment with I-PRF, iodine, or laser in smokers and non-smokers
This trial tests whether adding I-PRF (a concentrate from your own blood), povidone-iodine, or laser treatment to standard deep-cleaning helps smokers and non-smokers with gum disease. You may qualify if you have moderate to severe gum disease with at least one bleeding pocket in each area of your mouth.
Tunis, Mont FleuryAges 18 years+ - NCT03997552Recruiting
Gum surgery options to help regenerate damaged gum bone
This trial compares two dental gum surgery approaches to see which better helps the gum and bone heal in people with periodontitis. It may help by improving the depth of gum pockets and supporting regrowth of damaged areas around teeth.
MurciaAges 18 years+ - NCT03997578Recruiting
Gum surgery for deep periodontal bone defects
This trial studies a specific gum surgery technique plus a biologic product to help fill deep gum/bone defects from periodontitis (gum disease). It may help reduce gum pocket depth and improve healing around affected teeth.
MurciaAges 18 years+ - NCT05964699Recruiting
Gum surgery comparison with a minimally invasive flap
This trial compares a minimally invasive gum surgery method (using Emdogain MI) versus a more traditional approach for treating localized gum pockets. It may help people by promoting gum healing and improving gum “attachment” around the teeth.
Dallas, TexasAges 30–75
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Common questions
- Are there clinical trials for periodontitis?
- Yes. Clin2 currently lists 281 recruiting periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.