Clin2
NCT07741643Possibly a fitNot yet recruiting

Seeing cancer during surgery for head and neck cancer

HNSCC,Larynx, Pharynx and Oral CavitySquamous Cell CarcinomaHead and Neck CancerHead and Neck Surgery

Treatments studied

Part of Cancer, Ear, nose & throat, Lungs & breathing clinical trials.

This study tests whether a combination of a targeted antibody (panitumumab) and a special dye can help surgeons see cancer cells more clearly during surgery. It may help ensure that all cancer is removed.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 1
Enrollment
30 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must be 18 years or older
  • You must have a diagnosis of head and neck cancer and be scheduled for surgery to remove the tumor
  • Your blood counts and kidney/liver function must be within acceptable limits
  • You cannot be allergic to iodine or have had bad reactions to antibody therapies
  • You must not have had a heart attack, stroke, or uncontrolled heart failure in the past 6 months
  • You must not be pregnant or breastfeeding

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06819228Recruiting· Phase 1
Lighted antibody imaging in head and neck cancer surgery

This trial tests a special fluorescent dye attached to panitumumab, a cancer-targeting antibody, to help surgeons see tumor tissue more clearly during head and neck cancer surgery. The goal is to improve removal of all cancer cells while sparing healthy tissue.

Nashville, Tennessee
NCT04511078Recruiting· Phase 2
Panitumumab-IRDye800 during head and neck surgery

This Phase 2 study tests a targeted medicine (panitumumab-IRDye800) given around the time of surgery for head and neck squamous cell cancer. It aims to improve doctors’ ability to find and remove cancer tissue during planned surgery.

Birmingham, Alabama
NCT05945875Recruiting· Phase 1
Dual scans to find head and neck cancer spread

This early-stage study tests two different imaging (scanning) methods to better detect head and neck cancer. Your results from the scans may help doctors see where disease is before standard surgery to remove lymph nodes in the neck.

Nashville, Tennessee
NCT05901545Recruiting· Phase 1
Test an iodine-labeled drug to map neck lymph nodes

This Phase 1 study tests a labelling of panitumumab with iodine (111In) to see how well it can identify lymph nodes in head and neck cancer before surgery. The goal is to improve lymph node staging (which can help guide treatment), with the main focus on safety and early performance.

Nashville, Tennessee
NCT03582124Recruiting· Phase 1/Phase 2
Panitumumab dye to help find lung cancer during surgery

This trial tests a special dye drug (panitumumab-IRDye800) that may help surgeons better see lung cancer areas while operating. If it works, it could improve how well cancer tissue is found and removed during planned lung surgery.

Palo Alto, California
NCT07460765Recruiting· Phase 1
Nivolumab with a special dye for head and neck cancer surgery

This trial tests if a special dye attached to the drug nivolumab can help surgeons see cancer cells more clearly during surgery. If you have head and neck cancer and are scheduled for surgery, this study might be an option for you.

Nashville, Tennessee

Hear when a new Squamous Cell Carcinoma trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.