Brain implant or ear nerve stimulation for severe depression
Part of Mental health clinical trials.
This trial tests two brain-stimulation approaches for people whose depression hasn't improved with standard treatments. It aims to see if these methods can reduce symptoms by directly targeting specific brain regions.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 18 and 70 years old.
- You have been living with depression for at least 2 years.
- You have tried at least two different antidepressants for 8 weeks or more without much improvement.
- You have a moderate to severe level of depression (score > 17 on a standard scale).
- You are currently on a stable dose of your antidepressant for at least a month.
- You meet one or more of these: depression started before age 18, you have had self-harm or suicidal thoughts/behaviors, or you have experienced a traumatic event.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests if deep brain stimulation (a device that sends tiny electrical pulses to mood-related brain areas) can help people with tough-to-treat depression. It uses brain-signal monitoring to see which patterns predict improvement.
This study tests a special kind of brain stimulation that can adjust to your brain signals while treating major depression that has not improved with standard treatments. It may help people with severe, long-term treatment-resistant depression, but it requires brain surgery and frequent visits.
This trial studies whether deep brain stimulation (DBS)—a surgically placed brain device—can reduce severe, long-lasting depression that hasn’t responded to many treatments. It may help people whose depression has persisted despite trying multiple antidepressant and other evidence-based therapies.
This study tests a small implant placed under the scalp that delivers targeted electrical stimulation to the brain to help people with severe depression that hasn't improved with antidepressant medications. The implant is designed to rebalance brain activity and reduce depressive symptoms.
This trial tests a non-invasive brain-computer interface (BCI) to help people with depression. It may be a good fit for teenagers and adults who are right-handed, Han Chinese, and have moderate to severe depression without other major health problems.
This trial tests a brain pacemaker (deep brain stimulation) to see if it can help people whose depression has not improved with standard medications. It aims to reduce severe depression symptoms that haven't responded to other treatments.
Hear when a new Treatment-Resistant Major Depressive Disorder trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.