Study of orforglipron for people with overweight at risk of health problems
Treatments studied
Part of Heart & circulation, Hormones & metabolism clinical trials.
This trial tests a new medicine, orforglipron, to help people with overweight who are at risk of developing weight-related health issues. It aims to see if the medicine can help with weight management and reduce risks before more serious conditions develop.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be overweight, defined as having a body mass index (BMI) between 25 and 30.
- Your waist measurement should be high compared to your height (waist-to-height ratio at least 0.5).
- You must have at least one early sign of a weight-related problem, such as slightly high blood sugar, slightly high blood pressure, or slightly abnormal cholesterol levels.
- You must have tried to lose weight with diet and exercise at least once but not succeeded.
- You must not have diabetes, high blood pressure, or cholesterol problems that are already diagnosed or treated.
- Your weight must have been stable for the 90 days before the study starts.
- You cannot have taken any weight-loss medication or had weight-loss surgery in the past.
- You must not have ever had a BMI of 30 or higher, which would be classified as obesity.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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