Brain protein changes after hip or knee replacement surgery
Part of Brain & nervous system, Mental health clinical trials.
This study looks at whether having hip or knee replacement surgery with spinal anesthesia affects certain proteins in the brain that are linked to memory and thinking. It compares people having surgery with people who have arthritis but are not having surgery, to help understand if the surgery causes any short-term brain changes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Between 55 and 75 years old
- Generally healthy (classified as ASA 1 or 2)
- Having hip or knee replacement with spinal anesthesia, OR have hip/knee arthritis and are not planning surgery
- No severe memory or thinking problems (score at least 23 on a standard memory test)
- No inflammatory diseases (like rheumatoid arthritis or lupus)
- No serious heart or lung disease
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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