Advanced or Metastatic Non-small Cell Lung Cancer clinical trials

Advanced Heart Catheter Testing for Stent Patients With Chest Pain

This study tests a detailed diagnostic procedure during heart catheterization for patients who previously had stents placed and now have chest pain or signs of heart stress. The goal is to better understand blood flow in treated arteries to guide treatment decisions.

Immunotherapy with chemotherapy for advanced esophageal cancer

This trial tests whether combining a new immunotherapy drug (adebrelimab) with standard chemotherapy can help shrink borderline resectable esophageal squamous cell carcinoma before surgery. The goal is to make tumors easier to remove and improve survival.

Digital Tools to Manage Sarcoma Treatment Side Effects

This study tests whether a digital app or online tool can help you better manage symptoms and side effects from your sarcoma treatment. Researchers want to see if tracking your symptoms online improves how you feel during cancer care.

Lattice Radiation for Large Tumors When Other Treatments Won't Help

This trial tests a special type of focused radiation therapy (called SBRT-Lattice) for large tumors in patients who can't benefit from surgery, chemotherapy, or standard radiation. The radiation uses a lattice pattern designed to treat the tumor while protecting healthy tissue nearby.

Immune therapy with chemotherapy for advanced cervical cancer

This trial tests two immune-boosting drugs (iparomlimab and tuvonralimab) combined with standard chemotherapy given before surgery for locally advanced cervical cancer. The goal is to shrink the cancer and improve survival chances.

New Drug Combination for Advanced Hormone-Receptor-Positive Breast Cancer

This study tests two drugs together—trastuzumab deruxtecan and ivonescimab—for advanced breast cancer that is hormone-receptor-positive but HER2-negative or HER2-low. These drugs work by targeting cancer cells in different ways and may help slow or shrink tumors in patients whose cancer has progressed after earlier treatments.

Testing ES502 for Advanced Pancreatic and Other Cancers

This early-stage trial tests a new drug called ES502 for patients with advanced cancers (including pancreatic cancer) that have a specific genetic mutation and certain immune markers. The study aims to find the right dose and see if it helps shrink tumors.

Study of Ipalotinib with Sunitinib and Olaparib before surgery for advanced ovarian cancer

This trial tests a combination of three drugs (Ipalotinib, Sunitinib, and Olaparib) given before surgery to shrink tumors in people with a specific type of advanced ovarian cancer that has a genetic marker called HRD-positive. The goal is to see if this treatment helps make surgery more effective.

Heart risks in older men on enzalutamide or darolutamide

This study looks at heart-related risks in older men with advanced prostate cancer who are taking enzalutamide or darolutamide. It may help doctors better understand how to manage heart health during treatment.

Testing IDOV-Immune for advanced solid tumors

This trial tests an investigational drug called IDOV-Immune for people with advanced solid tumors that have stopped responding to standard treatments. The goal is to see if it is safe and effective.

Personalized Post-Surgery Care Plan for Advanced Head and Neck Cancer

This study helps doctors create a personalized plan for follow-up treatment after surgery for advanced head and neck cancer. Researchers will use imaging scans and patient data to predict which patients need extra treatment and which ones can be monitored closely instead.

Ovarian cell injection for perimenopause symptom relief

This trial tests injecting special cells called Muse cells into the ovaries to help relieve perimenopause symptoms and possibly restore ovarian function. It may help women experiencing irregular periods, hot flashes, sleep problems, mood changes, or trouble thinking clearly.

Surveillance after positive FIT and normal colonoscopy

This trial studies the best way to follow up with people who had a positive FIT stool test (high blood level) but a normal colonoscopy. It aims to find the right schedule for future screening to catch any problems early.

Surgery for advanced rectal or anal cancer

This trial studies the results of a major surgery called pelvic exenteration for patients with advanced rectal or anal cancer that has spread to nearby tissues or bones but not to distant organs. The goal is to see how well the surgery works and how patients recover afterward.

Testing a new drug combination for advanced gallbladder cancer

This trial tests a combination of two chemotherapy drugs (gemcitabine and nab-paclitaxel) with two immunotherapy drugs (iparomlimab and tuvorilimab) for people with advanced gallbladder cancer that cannot be removed by surgery. The goal is to see if this combination can help shrink the cancer or slow its growth.

Testing a combination of drugs for advanced gallbladder and bile duct cancer

This trial tests whether adding a targeted therapy (anlotinib) to standard chemo plus an immunotherapy (camrelizumab) is more effective than chemo plus immunotherapy alone for advanced gallbladder or bile duct cancers that cannot be removed by surgery.

How lymph node changes affect rectal cancer outcomes

This trial looks at how much the lymph nodes respond to chemoradiation before surgery in people with locally advanced rectal cancer. It aims to understand if that response can predict long-term results and guide future treatment choices.

Rulonilimab + Chemo for Advanced Cervical Cancer

This trial tests a new drug called Rulonilimab combined with chemotherapy, with or without bevacizumab, as the first treatment for cervical cancer that has spread or come back. It’s for people whose tumors have a specific marker (PD-L1) and who haven’t had other treatments for advanced disease.

Treating high-risk cervical cancer with chemoradiation and immunotherapy

This trial tests a new drug called Cardenimumab combined with standard chemotherapy and radiation for women with high-risk cervical cancer. The goal is to see if adding this drug can improve outcomes for patients whose tumors are large, have spread to lymph nodes, or are stage IV.

HPV vaccine study for healthy relatives of patients

This trial tests two experimental vaccines to boost the immune system against HPV 16. Healthy relatives of patients with HPV 16 cancer receive the vaccines, then donate blood cells for research.

Testing two first-treatment options for advanced ovarian cancer

This Phase 2 trial compares two different treatment strategies as the first chemotherapy after surgery for advanced epithelial ovarian, peritoneal, or fallopian-tube cancer. It may help doctors find a more effective or better-tolerated approach for people in your situation.

Neoadjuvant Radiotherapy vs Upfront Surgery in Locally Advanced Proximal Rectal Cancer

Study of a new virus therapy for high-risk bladder cancer

This trial tests a new virus-based medicine, cretostimogene grenadenorepvec, given directly into the bladder for people with high-risk non-muscle-invasive bladder cancer. It may help prevent the cancer from coming back, especially for those who have not had BCG treatment or whose cancer did not respond to BCG.

MK-4884 study for advanced solid tumors

This early-stage study tests a new drug called MK-4884 in patients with advanced cancers that have spread. The trial includes colorectal, kidney, lung, and bile duct cancers, and aims to find the right dose and see if the drug helps shrink tumors.