Clinical trials
Advanced or Metastatic Solid Tumors clinical trials
Below are recruiting advanced or metastatic solid tumors clinical trials, each written for real people, not researchers. We’re tracking 4,769 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07802197Recruiting
Radiation before surgery for advanced rectal cancer
This trial compares giving radiation therapy before surgery versus going straight to surgery for people with advanced rectal cancer that has not spread to other parts of the body. It aims to see which approach may be better for controlling the cancer.
IstanbulAges 18 years+ - NCT07801274Recruiting
Focused radiation after spine surgery for metastatic tumors
This trial tests a precise type of radiation therapy given after spine surgery to treat cancer that has spread to the spine. The goal is to reduce pressure on the spinal cord and help control the disease with fewer side effects.
Tianjin, Tianjin MunicipalityAges 18–80 - NCT07793695RecruitingPhase 2
Zinc plus immune therapy for advanced liver cancer
This study tests whether adding zinc supplements to standard targeted and immunotherapy improves outcomes for people with advanced liver cancer. Zinc may help the immune system work better against cancer cells.
Hefei, AnhuiAges 18–75 - NCT06517953RecruitingPhase 2
Testing two targeted pills for rare EGFR lung cancer
This study tests two oral targeted drugs, Befotertinib and Icotinib, in people with advanced lung cancer (NSCLC) that has one of three uncommon EGFR mutations. The trial aims to see how well these pills work when used as the first treatment for your cancer.
Guangzhou, GuangdongAges 18 years+ - NCT07795619Recruiting
Study of a new treatment for advanced bile duct cancer
This trial is testing a new treatment called HCA nano for a type of bile duct cancer that cannot be removed by surgery and has not spread. It is for patients whose cancer did not grow after standard chemotherapy.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07799935Recruiting
Tumor ablation after chemo for advanced pancreatic cancer
This study tests a procedure called irreversible electroporation (IRE), which uses electric pulses to destroy cancer cells, after chemotherapy for advanced pancreatic cancer that hasn't spread. It aims to control the tumor and improve outcomes in people who are not eligible for surgery.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07797816RecruitingPhase 2
Targeted drug combo with radiation for advanced bile duct cancer
This trial tests a combination of two chemotherapy drugs and an immunotherapy drug, followed by targeted radiation, in people with bile duct or gallbladder cancer that cannot be removed with surgery. The goal is to see if this approach can shrink tumors and improve outcomes.
Nanjing, JiangsuAges 18–80 - NCT05764044RecruitingPhase 3
Chemo after chemoradiation for HPV-positive cervical cancer
This Phase 3 study tests whether giving additional (adjuvant) chemotherapy after standard chemoradiation can help people whose blood test still shows cancer-related HPV DNA. It may help by lowering the risk of the cervical cancer coming back in people who have a positive blood biomarker after treatment.
Manaus, AmazonasAges 18–70 - NCT06387628RecruitingPhase 2
LM-108 with immunotherapy for advanced triple-negative breast cancer
This trial tests a new drug called LM-108 combined with a PD-1 inhibitor (a type of immunotherapy) for people with triple-negative breast cancer that has come back or spread. It aims to see if this combination can help shrink tumors or slow the disease.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06530316Recruiting
RET inhibitor before surgery for advanced thyroid cancer with RET changes
This trial tests a targeted drug (a RET inhibitor) taken before surgery to help shrink thyroid cancer that has a specific genetic change (RET alteration). It may make surgery easier or more successful.
ShanghaiAges 14–80 - NCT07789210RecruitingPhase 2
Neoadjuvant targeted therapy for BRAF-mutant colorectal cancer
This trial is testing a combination of two targeted drugs (encorafenib and cetuximab) with standard chemotherapy before surgery in people with a specific type of colorectal cancer that has the BRAF V600E mutation and is locally advanced or has limited spread. The goal is to see if this treatment can shrink tumors and improve outcomes.
Hangzhou, ZhejiangAges 18–75 - NCT07789093Recruiting
Coaching support for advanced cancer patients and caregivers
This trial tests a coaching program to help patients with advanced cancer and their caregivers prepare for and recover from palliative surgery or procedures that aim to relieve symptoms and improve quality of life. It explores whether this coaching improves communication and well-being.
SingaporeAges 21–99 - NCT07791745RecruitingPhase 2/Phase 3
Comparing treatments for advanced head and neck cancer
This trial tests a new combination of treatments for head and neck cancer that has returned or spread and can't be cured with local therapy. It compares a standard chemotherapy with or without an additional drug to see which is more effective and safe.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06532461Recruiting
Comparing 3 vs 7 day insulin pump wear in teens with type 1 diabetes
This study tests if wearing an insulin pump set for 7 days is as safe and effective as changing it every 3 days. It is for children and teens with type 1 diabetes who already use the Medtronic 780G system.
Herlev, CapitalAges 7–18 - NCT05892354Recruiting
Immunonutrition to reduce mouth sores after cancer treatment
This trial studies whether special nutritional supplements (immunonutrients) can reduce painful mouth sores (oral mucositis) in people with nasopharyngeal cancer after chemoradiotherapy. If you qualify, you’ll be followed with visits and lab tests to see if the supplements improve comfort and recovery.
Fuzhou, FujianAges 18–70 - NCT06543069RecruitingPhase 2
Combination therapy for unresectable peritoneal mesothelioma
This trial tests a combination of four drugs (sintilimab, bevacizumab, pemetrexed, and cisplatin) to see if they can shrink or control peritoneal mesothelioma that cannot be surgically removed. It may be an option if you have this rare cancer and are in fairly good health.
BeijingAges 18 years+ - NCT06377735Recruiting
BAI-BACE for advanced lung squamous cell carcinoma
This trial is testing a new use of a procedure called BAI-BACE (injecting drugs or blocking blood flow through the bronchial artery) for people with advanced lung squamous cell carcinoma that hasn't responded to prior treatments. The goal is to see if this treatment can help control the cancer when it's still only in the chest.
Beijing, Beijing MunicipalityAges 18–80 - NCT05837260Recruiting
Tracking tumor DNA changes in advanced thyroid cancers
This study looks at a small blood test (called ctDNA) and tumor tissue to understand how advanced thyroid cancers change over time. It may help doctors better monitor cancer growth and guide treatment choices.
LondonAges 18 years+ - NCT06100497RecruitingPhase 2
PD-1 plus chemo for advanced head and neck cancer
This trial tests a combination of immunotherapy (PD-1) and chemotherapy for people with advanced head and neck cancers that are poorly differentiated. The goal is to see if the combination helps shrink tumors before possible surgery or radiation.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06548919Recruiting
Treatment patterns for ESR1-mutated advanced breast cancer
This study looks at how Chinese patients with a specific gene change (ESR1 mutation) in ER-positive, HER2-negative advanced breast cancer are currently being treated. It will help doctors understand what treatments work best for people whose cancer has stopped responding to hormone therapy.
Suzhou, JiangsuAges 18 years+ - NCT07776691RecruitingPhase 3
Study of Raludotatug Deruxtecan for Advanced Ovarian Cancer
This study tests a new drug (raludotatug deruxtecan) with or without another drug (bevacizumab) as maintenance therapy after initial chemotherapy for advanced ovarian cancer. It aims to see if this combination can help keep the cancer from coming back.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06560528RecruitingPhase 2
Drug combo before & after surgery for HER2+ stomach cancer
This trial tests a combination of three drugs (targeted therapy, immunotherapy, and chemotherapy) before and after surgery for locally advanced HER2-positive stomach cancer. It aims to see if this treatment can improve outcomes for patients whose cancer has not yet spread.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT06551207Recruiting
New drug combo with radiation for advanced MSS colon cancer
This trial tests a new combination—an immunotherapy drug (cadonilimab) plus a targeted anti-angiogenesis pill (fruquintinib) and focused radiation (SBRT)—for people with MSS colorectal cancer that has progressed after at least two prior treatments. The goal is to see if this triple approach can help shrink or control the cancer better than standard options.
Wuhan, HubeiAges 18–75 - NCT07781358RecruitingPhase 2
Testing a new drug combination for recurrent nasopharyngeal cancer
This trial tests a new drug combination for people whose nasopharyngeal cancer has come back in the same area or nearby lymph nodes. The goal is to see if this treatment can shrink or control the cancer.
Shanghai, Shanghai MunicipalityAges 18–80
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Common questions
- Are there clinical trials for advanced or metastatic solid tumors?
- Yes. Clin2 currently lists 4,769 recruiting advanced or metastatic solid tumors studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced or metastatic solid tumors trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced or metastatic solid tumors trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Solid Tumors
- Advanced/Metastatic Solid Tumors
- Locally Advanced (Unresectable) or Metastatic Solid Tumors
- Locally Advanced/Metastatic Solid Tumors
- Patients With Advanced Solid Tumors
- Mesothelin-positive Advanced Malignant Solid Tumors
- Recurrent or Metastatic Solid Tumors
- Advanced Solid Tumor
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.