Clinical trials
Advanced or Metastatic Solid Tumors clinical trials
Below are recruiting advanced or metastatic solid tumors clinical trials, each written for real people, not researchers. We’re tracking 4,767 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06449313RecruitingPhase 2
Immunotherapy before lung cancer surgery for stage 3 disease
This trial tests whether giving chemotherapy plus immunotherapy before surgery can help shrink stage 3 lung cancer and improve outcomes. The goal is to make the tumor easier to remove and possibly lower the chance of it coming back.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06448572RecruitingPhase 1/Phase 2
EXL01 and nivolumab for immunotherapy-resistant lung cancer
This trial tests an investigational microbiome therapy (EXL01) combined with nivolumab (an immunotherapy) for people with advanced non-small cell lung cancer whose cancer continued to grow after standard immunotherapy and chemotherapy. The goal is to see if adding EXL01 can help the immune system fight the cancer again.
LilleAges 18 years+ - NCT05934331RecruitingPhase 2
Study for CLDN18.2-positive advanced gut cancers after first treatment
This Phase 2 trial tests a combination anti-cancer medicine (LM-302) plus other anti-tumor treatments for advanced gastrointestinal cancers. It’s designed for people whose tumors test positive for CLDN18.2 and who have already tried standard first-line treatment but didn’t respond or couldn’t tolerate it.
ShanghaiAges 18–80 - NCT03958240Recruiting
Study how cancers trigger the immune system
This study looks at what makes some cancers more “noticeable” to the immune system. It may help researchers design better future immunotherapy by collecting information (often including blood samples) from people with different cancers.
ToulouseAges 18 years+ - NCT06427954Recruiting
Mobile app study for people with advanced lung cancer
This study tests a mobile app (called THRIVE) to help people with advanced lung cancer manage their health and well-being. You'll use the app on your phone to track symptoms and get support, which may help you feel better and stay more in control.
Los Angeles, CaliforniaAges 18 years+ - NCT06427239RecruitingPhase 1/Phase 2
HRS-4642 and adebrelimab for advanced pancreatic cancer
This trial tests a combination of two drugs (HRS-4642 and adebrelimab) for people with advanced pancreatic cancer that has not responded to standard treatment. The goal is to see if this combination can shrink tumors or slow the disease.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06432491Recruiting
Core Temperature and Health in Healthy Adults 50–65
This study will look at how core body temperature relates to your overall health, by monitoring temperature patterns in healthy adults aged 50–65 who live in Shenzhen. It aims to find connections that could help predict or prevent health issues.
Shenzhen, GuangdongAges 50–65 - NCT06433011Recruiting
New clot-busting method for pulmonary embolism
This study tests a new way of delivering a clot-dissolving medicine for people with a serious but not immediately life-threatening pulmonary embolism. The goal is to see if giving the medicine as small bursts directly into the clot can help the heart recover faster.
Scottsdale, ArizonaAges Any age - NCT03758976Recruiting
Study of scans in advanced breast cancer recurrence
This study looks at people with advanced breast cancer to better understand recurrence by using information from recent scans. It may help researchers improve how advanced disease is assessed and followed over time.
LundAges 18 years+ - NCT06417801Recruiting
Study of ESR1 gene changes in blood in advanced breast cancer
This study looks for changes in the ESR1 gene in the blood of people with advanced HR+/HER2- breast cancer. It compares these blood test results with tumor tissue results to learn more about the cancer.
Salvador, Estado de BahiaAges 18–100 - NCT06420206Recruiting
Goals of care discussion in the ER for advanced cancer
This study is for people with advanced lung or GI cancer who come to the emergency room at MD Anderson. It’s testing a conversation to help you and your doctor discuss your goals and wishes for care.
Houston, TexasAges 18 years+ - NCT06409390RecruitingPhase 2
Sequential therapy based on tumor evolution for breast cancer
This trial tests a sequence of different treatments for breast cancer that has spread, based on how the cancer evolves. The goal is to find a personalized treatment plan that may work better over time.
Tampa, FloridaAges 18 years+ - NCT06414590RecruitingPhase 2
Tebentafusp before surgery for eye melanoma
This trial tests a drug called Tebentafusp for a type of eye melanoma (uveal melanoma) that is too large to be removed without taking out the whole eye. The goal is to see if the drug can shrink the tumor before deciding on surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06409065Recruiting
Emotional and spiritual support for advanced cancer and caregivers
This study offers a program to help people with advanced cancer and their caregivers cope with emotional and spiritual distress. It involves talking with a counselor together to improve your well-being.
Houston, TexasAges 18 years+ - NCT06399991Recruiting
Improving mental health care in Malawi clinics
This study is testing a new way to help clinics in Malawi better support patients with mental health needs. If you are an adult patient at a participating clinic who has recently had symptoms of depression or anxiety, you may be eligible.
ChiradzuluAges 18 years+ - NCT06419257Recruiting
Virtual reality driving for dementia patients
This trial tests if a virtual reality driving simulator can help people with dementia living in a special care unit. If you can walk and see well, you may be able to take part.
Winnipeg, ManitobaAges 50 years+ - NCT06400849Recruiting
Cooling and compression to prevent nerve damage from chemo
This trial tests whether adding a cooling and compression treatment to your hands and feet during chemotherapy can help prevent nerve damage (neuropathy) caused by the drug paclitaxel. It may be a good option for people with breast cancer who are about to start this type of chemotherapy and want to reduce side effects.
NiceAges 18–99 - NCT05794061Recruiting
Testing new ways to assess brain and behavior health
This study is developing and checking better tests to understand neurological (brain-related) and psychiatric (mental health) conditions. If you have a diagnosed brain or mental health condition—or you’re being considered as a healthy person—your results will help researchers see how well these assessments work.
Milan, LombardyAges 20–100 - NCT05968690RecruitingPhase 1
Testing naltrexone and propranolol with melanoma immunotherapy
This Phase 1 study tests whether adding naltrexone and propranolol to standard immunotherapy (ipilimumab plus nivolumab) can improve outcomes for people with advanced melanoma. It also aims to better understand safety and how the combination works in the body.
New Brunswick, New JerseyAges 18 years+ - NCT06389799RecruitingPhase 2
Pemigatinib and Retifanlimab for Advanced Liposarcoma
This trial tests two experimental drugs (pemigatinib and retifanlimab) for advanced dedifferentiated liposarcoma that has not responded to other treatments. It aims to see if this combination can shrink tumors or slow cancer growth.
OsloAges 18–100 - NCT06383221Enrolling by invitation
Psychological and prenatal support for depression or anxiety in pregnancy
This trial tests a step-by-step program that combines psychological support and prenatal care to help pregnant women manage depression or anxiety. It is designed for women who have screened positive for these symptoms but are not yet receiving treatment.
Ma’anshanAges 18 years+ - NCT06380530Recruiting
Computer-assisted surgical planning for limb deformity correction
This trial tests a new computer-assisted planning method to help surgeons better correct bone deformities in the arms or legs. It may lead to more precise surgeries and faster recovery.
Bologna, BOAges 2–40 - NCT06380101Recruiting
Special diet with standard therapy for rectal cancer
This trial tests a special medical food that limits certain amino acids (building blocks of protein) during standard treatment for rectal cancer. The goal is to see if this diet helps the treatment work better while reducing side effects.
Tampa, FloridaAges 18–100 - NCT06389097Recruiting
SPECT Scans to Improve Treatment for Advanced Cancer
This study uses special scans (SPECT imaging) to see how radium or lutetium treatments move through your body, helping doctors plan better doses. It's for people with advanced prostate cancer (getting Radium-223) or advanced neuroendocrine tumors (getting 177Lu treatments).
Baltimore, MarylandAges 18–100
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Common questions
- Are there clinical trials for advanced or metastatic solid tumors?
- Yes. Clin2 currently lists 4,767 recruiting advanced or metastatic solid tumors studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced or metastatic solid tumors trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced or metastatic solid tumors trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Solid Tumors
- Advanced/Metastatic Solid Tumors
- Locally Advanced (Unresectable) or Metastatic Solid Tumors
- Locally Advanced/Metastatic Solid Tumors
- Patients With Advanced Solid Tumors
- Mesothelin-positive Advanced Malignant Solid Tumors
- Recurrent or Metastatic Solid Tumors
- Advanced Solid Tumor
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.