Clinical trials
Advanced clinical trials
Below are recruiting advanced clinical trials, each written for real people, not researchers. We’re tracking 3,986 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06005324RecruitingPhase 1
Personalized treatment for advanced head and neck cancer
This trial tests a custom treatment plan for people with advanced head and neck cancer that is not caused by HPV. It combines radiation and chemotherapy with a targeted drug called cetuximab, adjusted based on your tumor's characteristics.
Chicago, IllinoisAges 18 years+ - NCT06509490Recruiting
CAR-T cell therapy for advanced NKG2DL-positive solid tumors
This trial tests a new type of immune cell therapy (NKG2D CAR-T cells) for people with advanced solid tumors that have not responded to standard treatments. It aims to see if these specially engineered cells can shrink tumors or slow their growth.
Beijing, Beijing MunicipalityAges 18–70 - NCT02333110Recruiting
Grid radiation therapy for advanced, painful tumors
This trial tests a way of giving palliative radiation using a “grid” to treat advanced tumors that are large, resistant to standard radiation, or already needed more than one palliative radiation session. It may help better control symptoms when a cure is not the goal.
Montreal, QuebecAges 18 years+ - NCT06987370Recruiting
Radiation study for bone metastases with soft tissue mass
This trial tests a new way of giving radiation (SFRT and SCART) to bone metastases that have a soft tissue mass. It may be an option if you have limited spread and your organs are working well.
Jinan, ShandongAges 18–75 - NCT06492746Recruiting
Blood pressure monitoring during heart surgery
This trial tests a new method to monitor blood pressure during heart surgery that uses a heart-lung machine. It is for people at higher risk for stroke or other brain blood vessel issues.
Evanston, IllinoisAges 45 years+ - NCT07467629RecruitingPhase 1
Study of QLS5212 for people with advanced solid tumors
This trial tests a new drug called QLS5212 in people with solid tumors that have spread or cannot be removed by surgery. The goal is to see if the drug is safe and effective.
TaiyuanAges 18 years+ - NCT07099274RecruitingPhase 2
Combination treatment for advanced liver cancer
This trial tests a combination of two immunotherapy drugs, TACE (a procedure to block blood flow to tumors), and lenvatinib (a targeted therapy) for people with liver cancer that has not responded to initial treatment. It aims to see if this combination can help shrink tumors or slow cancer growth.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06484660Recruiting
Less invasive surgery for complex anal fistula
This study tests a less invasive surgical method (a mucosal advancement flap) for treating complex anal fistulas. It aims to see if this approach works well for people who have a single fistula tunnel and haven't had this type of operation before.
Palma de Mallorca, Balearic IslandsAges 18 years+ - NCT06481956Enrolling by invitationPhase 2
T-DM1 plus a CDK4/6 inhibitor (ribociclib) for HER2-positive breast cancer
This clinical trial tests a combination of two targeted therapies for people with HER2-positive breast cancer that has spread or come back. The goal is to see if adding ribociclib to T-DM1 is safe and effective after other treatments have been used.
Hangzhou, ZhejiangAges 18–75 - NCT07098052RecruitingPhase 1
Study of HDM2020 for advanced solid tumors
This trial is testing a new drug called HDM2020 for people with advanced solid tumors that have not responded to other treatments. The goal is to see if the drug is safe and how well it works.
Guangzhou, GuangdongAges 18–75 - NCT07464483Recruiting
Studying genetics in stem cell and CAR-T therapy patients
This trial analyzes genetic information from patients receiving a stem cell transplant or CAR-T therapy to better understand treatment outcomes. Participation may help researchers improve future therapies.
Bologna, BolognaAges Any age - NCT07487597RecruitingEarly Phase 1
Engineered T cell therapy for ALPP-positive advanced solid tumors
This trial tests a new type of immune cell therapy designed to target and attack cancer cells that have a specific marker called ALPP. It is for people with advanced solid tumors who have not responded to or cannot have standard treatments.
Nanjing, JiangsuAges 18–70 - NCT06419257Recruiting
Virtual reality driving for dementia patients
This trial tests if a virtual reality driving simulator can help people with dementia living in a special care unit. If you can walk and see well, you may be able to take part.
Winnipeg, ManitobaAges 50 years+ - NCT06394622RecruitingPhase 1
CAR-NKT cells targeting CD70 for advanced solid tumors
This trial tests a new type of immune cell therapy (CAR-NKT) that targets a protein called CD70 on cancer cells. It is for people with advanced solid tumors that have not responded to at least two prior treatments and whose tumors are CD70-positive.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07094685RecruitingPhase 2
Ivonescimab before surgery for head and neck cancer
This study tests a new immunotherapy drug called ivonescimab given before surgery for people with advanced head and neck cancer. The goal is to see if it helps shrink the tumor and improve outcomes.
Ann Arbor, MichiganAges 18 years+ - NCT06383221Enrolling by invitation
Psychological and prenatal support for depression or anxiety in pregnancy
This trial tests a step-by-step program that combines psychological support and prenatal care to help pregnant women manage depression or anxiety. It is designed for women who have screened positive for these symptoms but are not yet receiving treatment.
Ma’anshanAges 18 years+ - NCT06361589Recruiting
Lorlatinib for advanced ALK-positive lung cancer
This study is testing a targeted therapy called lorlatinib in people with advanced ALK-positive lung cancer. It aims to see how well this oral medication works in a real-world setting.
Chengdu, SichuanAges 18 years+ - NCT06314087RecruitingPhase 2
Personalized cancer vaccine with radiation therapy
This trial tests a personalized cancer vaccine combined with a special type of radiation therapy for people with advanced or recurrent cancers that no longer respond to standard treatments. The goal is to help your immune system better recognize and attack your cancer.
Shenzhen, GuangdongAges 18–80 - NCT06616298Recruiting
Aligning care for older adults with cancer in nursing facilities
This study tests a program called ALIGN that helps older adults with cancer transition from a hospital to a skilled nursing facility (SNF). It aims to improve care coordination and quality of life.
Aurora, ColoradoAges 18–98 - NCT06301438Recruiting
Dalpiciclib for HR+/HER2- advanced breast cancer
This trial tests a drug called Dalpiciclib for people with a certain type of advanced breast cancer (HR-positive, HER2-negative). It aims to see if it can help stop the cancer from growing.
ShanghaiAges 18 years+ - NCT07235202RecruitingPhase 1/Phase 2
MR001 plus chemo for advanced pancreatic cancer after first treatment
This trial tests a new drug, MR001, combined with chemotherapy for people whose pancreatic cancer has spread and no longer responds to their first treatment. It aims to see if this combination can help shrink tumors or slow the disease.
Beijing, Beijing MunicipalityAges 18–75 - NCT06479759RecruitingPhase 2
LM-108 with sintilimab for advanced lung cancer
This trial tests a new antibody combination for non-small cell lung cancer that has spread or come back. It may help people whose cancer stopped responding to immunotherapy or who haven't had treatment yet.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06477991Recruiting
No surgery after immunotherapy for MSI-H colorectal cancer
This trial is studying whether some people with a specific type of advanced colorectal cancer (MSI-H/dMMR) might be able to skip surgery after immunotherapy. Doctors will use a blood test (MRD monitoring) to track the cancer, and then decide whether to keep an eye on it or operate.
Kunming, YunnanAges 18–75 - NCT07664150RecruitingPhase 1/Phase 2
Testing a new drug for HER2-positive cancers after other treatments stop working
This trial tests a new drug, CAN016, for people with advanced solid tumors that have HER2 expression or a HER2 gene change. You may qualify if your cancer has gotten worse after trying other HER2-targeted treatments.
Beijing, Beijing MunicipalityAges 18 years+
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Common questions
- Are there clinical trials for advanced?
- Yes. Clin2 currently lists 3,986 recruiting advanced studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.